Plabon Kumar Das, Farhadul Islam, Alfred K. Lam
Cancer stem cells (CSCs) are the main culprits involved in therapy resistance and disease recurrence in colorectal carcinoma (CRC). Results using cell culture, animal models and tissues from patients with CRC suggest the indispensable roles of colorectal CSCs in therapeutic failure. Conventional the...
Plabon Kumar Das, Suja Pillai, Md. Abdur Rakib, Jahan Ara Khanam et al.
In embryonic development and throughout life, there are some cells can exhibit phenotypic plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In normal development, plasticity is highly regulated whereas cancer cells re-activate this dynamic ability for...
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K. Lam et al.
Estrogens have been implicated in the pathogenesis of various cancer types, including colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular signaling cascades followed by binding to estrogen, resulting in important changes in cellular behaviors. The nuclear estrog...
Plabon Kumar Das, Tasnim Zahan, Md. Abdur Rakib, Jahan Ara Khanam et al.
BACKGROUND: Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence. METHODS: A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google s...
Plabon Kumar Das, Mst. Ayesha Siddika, Saharia Yeasmin Asha, Suraiya Aktar et al.
Reactivation of the stem cell programme in breast cancer is significantly associated with persistent cancer progression and therapeutic failure. Breast cancer stem cells (BCSCs) are involved in the process of breast cancer initiation, metastasis and cancer relapse. Among the various important cues f...
Plabon Kumar Das, Farhadul Islam, Robert A. Smith, Alfred K. Lam
Cancer stem cells (CSCs) in esophageal cancer have a key role in tumor initiation, progression and therapy resistance. Novel therapeutic strategies to target CSCs are being tested, however, more in-depth research is necessary. Eradication of CSCs can result in successful therapeutic approaches again...
Tasnim Zahan, Plabon Kumar Das, Syeda Farida Akter, Rowshanul Habib et al.
BACKGROUND: Chemoresistance is a vital problem in cancer therapy where cancer cells develop mechanisms to encounter the effect of chemotherapeutics, resulting in cancer recurrence. In addition, chemotherapy- resistant leads to the formation of a more aggressive form of cancer cells, which, in turn, ...
Plabon Kumar Das, Md. Abdur Rakib, Jahan Ara Khanam, Suja Pillai et al.
BACKGROUND: Breast cancer remains to be one of the deadliest forms of cancers, owing to the drug resistance and tumor relapse caused by breast cancer stem cells (BCSCs) despite notable advancements in radio-chemotherapies. OBJECTIVES: To find out novel therapeutics against breast cancer stem cells b...
Plabon Kumar Das, Saharia Yeasmin Asha, Ichiro Abe, Farhadul Islam et al.
Anaplastic thyroid cancer (ATC) remains as one of the most aggressive human carcinomas with poor survival rates in patients with the cancer despite therapeutic interventions. Novel targeted and personalized therapies could solve the puzzle of poor survival rates of patients with ATC. In this review,...
Suraiya Aktar, Plabon Kumar Das, Saharia Yeasmin Asha, Mst. Ayesha Siddika et al.
Angiotensin Converting Enzyme (ACE) regulates blood pressure. ACE converts angiotensin I to angiotensin II which binds with its receptors and through a cascade of reactions constrict blood vesels, consequently results in increased blood pressure, called hypertension. Inhibition of ACE activity is co...
Plabon Kumar Das, Ayesha Siddika, K M Rashel, Abdul Auwal et al.
INTRODUCTION: Long noncoding RNAs (lncRNAs) play crucial roles in regulating various hallmarks in cancers. Triple-negative (Estrogen receptor, ER; Human epidermal growth factor receptor 2, HER2; Progesterone receptor, PR) breast cancer (TNBC) is the most aggressive form of breast cancers with a poor...
Plabon Kumar Das, Saharia Yeasmin Asha, Mst. Ayesha Siddika, Ayesha Siddika et al.
Cancer is one of the vital causes of morbidity and mortality worldwide and recognized as the second most leading cause of death. Considering the side effects and high cost of synthetic anticancer drugs, plant might act as a source of novel anticancer agents with better host safety. In this investiga...
Ayesha Siddika, Plabon Kumar Das, Saharia Yeasmin Asha, Suraiya Aktar et al.
BACKGROUND: Syzygium cumini is one of the evidence-based traditional medicinal plant used in the treatment of various ailments. OBJECTIVES: Herein, the antioxidant property and anticancer property of Syzygium cumini against Ehrlich Ascites Carcinoma (EAC) cells were examined to find effective chemot...
Ruksana Yesmin, Plabon Kumar Das, Hazrat Belal, Suraiya Aktar et al.
Background: Adverse side effects of currently available therapies against cancer, leads scientists to find effective compounds from natural sources. Objective: In the present study, stem-bark of Mycelia champaca is subjected to evaluate its antiproliferative effect against Ehrlich Ascites Carcinoma ...
Sajal K. Das, N. Mondol, M. S. Raña, Plabon Kumar Das
This paper presents the real time implementation of genetic algorithm (GA) based PI controller tuning for position control of DC motor. Here the initial value of proportional gain and integral gain of PI controller are selected from well recognized Ziegler Nichols tuning formula and then optimized b...