Rubhana Raqib, Protim Sarker, Peter Bergman, Gul Ara et al.
Shigella is a major cause of morbidity, mortality, and growth retardation for children in developing countries. Emergence of antibiotic resistance among Shigellae demands the development of effective medicines. Previous studies found that the endogenous antimicrobial peptide LL-37 is down-regulated ...
Rubhana Raqib, Dewan S Alam, Protim Sarker, Shaikh Meshbahuddin Ahmad et al.
Background Low birth weight is generally an outcome of a fetal insult or nutritional insufficiency. Recent studies have shown that such exposure early in life may have long-term implications for later immunocompetence and susceptibility to infectious diseases. Objective We aimed to investigate the e...
Protim Sarker, Sultan Ahmed, Snigdha Tiash, Rokeya Sultana Rekha et al.
BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulat...
Rubhana Raqib, Protim Sarker, Akhirunnesa Mily, Nur Alam et al.
BACKGROUND: Treatment of shigellosis in rabbits with butyrate reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia. Here, we aimed to evaluate whether butyrate can be used as an adjunct to antibiotics in the treatment of shigellosis ...
Akhirunnesa Mily, Rokeya Sultana Rekha, S. M. Mostafa Kamal, Evana Akhtar et al.
BACKGROUND: We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D3 for induction of LL-37 expression in i...
M. Jubayer Rahman, Protim Sarker, Roy Sk, Shaikh Meshbahuddin Ahmad et al.
Background Zinc is lost during diarrheal diseases, and zinc deficiency induces intestinal morphology-altering inflammatory responses that zinc supplementation can correct. Objective We assessed the in vivo effect of zinc supplementation on systemic and mucosal responses in mildly to moderately malno...
Rubhana Raqib, Firdausi Qadri, Protim Sarker, S. M. Shahjahan Mia et al.
We hypothesized that increased susceptibility to Shigella infection, increased severity of disease and high mortality in children compared with adults were consequences of insufficient adaptive immune responses. Antigen-specific immune responses were studied in paediatric patients (n = 38, 2-10 year...
Håkan Ottosson, Frank Nylén, Protim Sarker, Erica Miraglia et al.
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in...
Rubhana Raqib, Pricila Khan Moly, Protim Sarker, Firdausi Qadri et al.
Cells of the innate immune system and their mediators were studied at the single-cell level in the rectums of pediatric and adult patients with Shigella infection to better understand why children are at higher risk for severe infection. Adult patients had increased infiltration of mucosal mast cell...
Rubhana Raqib, Protim Sarker, Khalequ Zaman, Nur Alam et al.
Shigella sonnei live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-desce...
Protima Sarker, Xin Liu, Naoki Hata, Hiroki Takeshita et al.
Phosphate recovery from wastewater using readily available biowaste-based adsorbents is beneficial for both eutrophication control and waste management. Bamboo char has a high-density porous structure and eggshell contains CaCO3 with high affinity for phosphate. The combination of calcined bamboo an...
Sourav Sarker, Shahin Mahmud, Razia Sultana, Ritu Biswas et al.
Water is one of the most vital elements of ecosystem and human being, but unfortunately nowadays, the pollution of surface and drinking water is an alarming problem. The present work deals with the assessment of physicochemical and bacteriological profile of several pond, jar and tube-well water sam...
Abdullah Al-Mamun, Akhirunnessa Mily, Protim Sarker, Snigdha Tiash et al.
Treatment of shigellosis in rabbits with phenylbutyrate reduces clinical severity and counteracts down-regulation of cathelicidin (CAP-18) in the large intestinal epithelia. We aimed to further evaluate whether in a rabbit model of enteropathogenic Escherichia coli (EPEC) diarrhea, CAP-18 is down-re...
Md. Ahsanul Haq, Anjan Kumar Roy, Razu Ahmed, Rakib Ullah Kuddusi et al.
COVID-19 vaccines have been effective in preventing severe illness, hospitalization and death, however, the effectiveness diminishes with time. Here, we evaluated the longevity of antibodies generated by COIVD-19 vaccines and the risk of (re)infection in Bangladeshi population. Adults receiving two ...
Protim Sarker, Evana Akhtar, Rakib Ullah Kuddusi, Mohammad Mamun Alam et al.
Background: The adaptive immune response is a crucial component of the protective immunity against SARS-CoV-2, generated after infection or vaccination. Methods: We studied antibody titers, neutralizing antibodies and cellular immune responses to four different COVID-19 vaccines, namely Pfizer-BioNT...