Ting Shi, David McAllister, Katherine L. O’Brien, Eric A. F. Simões et al.
BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on...
Fatimah S. Dawood, A. Danielle Iuliano, Carrie Reed, Martin I. Meltzer et al.
Background 18,500 laboratory-confirmed deaths caused by the 2009 pandemic influenza A H1N1 were reported worldwide for the period April, 2009, to August, 2010. This number is likely to be only a fraction of the true number of the deaths associated with 2009 pandemic influenza A H1N1. We aimed to est...
Ophira Ginsburg, Freddie Bray, Michel P. Coleman, Verna Vanderpuye et al.
Each year, more than 2 million women are diagnosed with breast or cervical cancer, yet where a woman lives largely determines whether she will develop one of these cancers, have access to timely and effective diagnostic and treatment services, and ultimately survive. Premature death and disability f...
Harish Nair, W. Abdullah Brooks, Mark Katz, Anna Roca et al.
Background The global burden of disease attributable to seasonal influenza virus in children is unknown. We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years. Methods We estimated the incidence of infl...
Harish Nair, Eric A. F. Simões, Igor Rudan, Bradford D. Gessner et al.
Background The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate the incidence of admissions and deaths for such infections in children younger than 5 years in 2010. Methods...
Annabelle Santos Volgman, Latha S. Palaniappan, Neelum T. Aggarwal, Milan Gupta et al.
South Asians (from Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka) make up one quarter of the world's population and are one of the fastest-growing ethnic groups in the United States. Although native South Asians share genetic and cultural risk factors with South Asians abro...
Xin Wang, You Li, Katherine L. O’Brien, Shabir A. Madhi et al.
BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this s...
Guillaume Constantin de Magny, Raghu Murtugudde, Mathew R. P. Sapiano, Azhar Nizam et al.
The causative agent of cholera, Vibrio cholerae , has been shown to be autochthonous to riverine, estuarine, and coastal waters along with its host, the copepod, a significant member of the zooplankton community. Temperature, salinity, rainfall and plankton have proven to be important factors in the...
Sudhin Thayyil, Stuti Pant, Paolo Montaldo, Deepika Shukla et al.
BACKGROUND: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive ca...
R. Krishnan, A. B. Shrestha, Guoyu Ren, Rupak Rajbhandari et al.
Historically, the climate of the HKH has experienced significant changes that are closely related to the rise and fall of regional cultures and civilizations. Studies show well-established evidence that climate drivers of tropical and extra-tropical origin—such as the El Niño-Southern Oscillation (E...
Xin Wang, You Li, Maria Deloria Knoll, Shabir A. Madhi et al.
BACKGROUND: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed vaccines or drugs exist for human metapneumovirus infectio...
Karabi Datta, Niranjan Baisakh, Moumita Ganguly, S. Krishnan et al.
Rice yield is greatly affected by environmental stresses such as drought and salinity. In response to the challenge of producing rice plants tolerant to these stresses, we introduced cDNA encoding the transcription factors DREB1A and DREB1B under the control of the stress inducible rd29 promoter. Tw...
Ian Heywood, I. Rammala, F. Camilo, W. D. Cotton et al.
Abstract The inner ∼200 pc region of the Galaxy contains a 4 million M ⊙ supermassive black hole (SMBH), significant quantities of molecular gas, and star formation and cosmic-ray energy densities that are roughly two orders of magnitude higher than the corresponding levels in the Galactic disk. At ...
Kartik Dhar, Suresh R. Subashchandrabose, Kadiyala Venkateswarlu, Kannan Krishnan et al.
Polycyclic aromatic hydrocarbons (PAHs) are a class of hazardous organic contaminants that are widely distributed in nature, and many of them are potentially toxic to humans and other living organisms. Biodegradation is the major route of detoxification and removal of PAHs from the environment. Aero...
Minxian Wang, Ramesh Menon, Sanghamitra Mishra, Aniruddh P. Patel et al.
Background: Genome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individuals may be particularly useful in this population. ...