Qian Li, Liwen Yu, Amy Gao, Ruiqing Ren et al.
Background: Atherosclerosis is a chronic inflammatory disease, in which macrophages determine the progression of atherosclerotic plaques. However, no studies have investigated how METTL3 (methyltransferase like 3) in macrophages affects atherosclerotic plaque formation in vivo. Additionally, whether...
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren et al.
Innate immunity is the first line to defend against pathogenic microorganisms, and Toll-like receptor (TLR)-mediated inflammatory responses are an essential component of innate immunity. However, the regulatory mechanisms of TLRs in innate immunity remain unperfected. We found that the expression of...
Jianlin Zhang, Yu Cao, Ruiqing Ren, Wenhai Sui et al.
Abstract Abdominal aortic aneurysm (AAA) is a life‐threatening vascular disease but effective drugs for treatment of AAA are still lacking. Recently, erythropoietin (EPO) is reported to induce AAA formation in apolipoprotein‐E knock out (ApoE −/− ) mice but an effective antagonist is unknown. In thi...
Jie Zhang, Liwen Yu, Wei� Yang, Lei Cao et al.
BACKGROUND: Atherosclerosis is a chronic inflammatory disease marked by lipid accumulation and immune cell infiltration in arterial walls. Macrophages contribute by internalizing oxidized low-density lipoprotein, forming foam cells, and driving inflammation. The ubiquitin–proteasome system regulates...
James Heckman, P Edward, Kevin Lazear, Murphy et al.
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