Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Sajib Chakraborty, Taibur Rahman
Cancer is clearly the most deadly disease in the developed world as one in three people develop cancer during their lifetime. The cure for cancer is like the Holy Grail since most of the existing treatments are not effective enough to provide full protection from this disease. In recent years the bu...
Selim Hossain, Rokeya Mumtahana Mou, Mohammed Mahedi Hasan, Sajib Chakraborty et al.
Tea is a popular beverage all around the world, and in Bangladesh the cultivation of tea plays a vital role. Many diseases affect the proper growth of tea leaves leading to its reduction, thus hindering of the production of tea. However, if the disease is identified at an early age it would solve al...
Rezaul Islam, Aubhishek Zaman, Iffat Jahan, Rajib Chakravorty et al.
UNLABELLED: Acetylcholine-esterase (AchE) inhibitors are one of the most potent drug molecules against Alzheimer's disease (AD). But, patients treated with current AchE inhibitors often experience severe side effects. Quercetin is a plant flavonoid compound which can act as AchE inhibitor and it may...
Sajib Chakraborty, Rajib Chakravorty, Musaddeque Ahmed, Atiqur Rahman et al.
A major problem in designing vaccine for the dengue virus has been the high antigenic variability in the envelope protein of different virus strains. In this study, a computational approach was adopted to identify a multi-epitope vaccine candidate against dengue virus that may be suitable for large ...
Tonmoy Das, Geoffroy Andrieux, Musaddeque Ahmed, Sajib Chakraborty
The manifestations of cancerous phenotypes necessitate alterations at different levels of information-flow from genome to proteome. The molecular alterations at different information processing levels serve as the basis for the cancer phenotype to emerge. To understand the underlying mechanisms that...
Md Kawsar Khan, Shabnam Zaman, Sajib Chakraborty, Rajib Chakravorty et al.
Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce the necessary immune response, thus providing a rational alternative to conventional design approaches. Using a range of immunoinformatics tools, we identified a novel, contiguous 28 amino acid multi-epitope ...
Sajib Chakraborty, Ambrosius P. Snijders, Rajib Chakravorty, Musaddeque Ahmed et al.
CRISPRs are a diverse family of DNA repeat sequences that are widely distributed among archaea and bacteria. The CRISPR locus is usually composed of three key elements; direct repeats (DRs), spacer sequences and the cas genes. Although recent studies have suggested that spacers may be of extrachromo...
Geoffroy Andrieux, Tonmoy Das, Michaela Griffin, Jakob Straehle et al.
BACKGROUND: Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic...
Abdullah Al Saba, Maisha Adiba, Piyal Saha, Md. Ismail Hosen et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest of the several viral pathogens that have acted as a threat to human health around the world. Thus, to prevent COVID-19 and control the outbreak, the development of vaccines against SARS-CoV-2 is one of the most important stra...
Sajib Chakraborty, Mohammed Mahedi Hasan, Md. Abdur Razzak
Sajib Chakraborty, Saruar Alam, Mohammad Sayem, Mousumi Sanyal et al.
BackgroundThe dengue-infected patients with or without hemorrhagic manifestations, typically exhibit moderate to severe thrombocytopenia. A thrombopoietin receptor agonist – eltrombopag has been efficacious in correcting thrombocytopenia in patients with various pathological conditions including imm...
Sajib Chakraborty, Geoffroy Andrieux, A. M. Mahmudul Hasan, Musaddeque Ahmed et al.
Proteome-centric studies, although have identified numerous lncRNA-encoded polypeptides, lack differential expression analysis of lncRNA-peptidome across primary tissues, cell lines and cancer states. We established a computational-proteogenomic workflow involving re-processing of publicly available...
Sajib Chakraborty, Mohammed Mahedi Hasan, Imane Worighi, Omar Hegazy et al.
A Proportional-Integral-Derivative (PID)-controlled synchronous buck converter (SBC)-based battery charging system was designed to charge a lead-acid cell battery using commercially available Photovoltaic (PV) panel. The proposed system was installed aboard a fishing trawler to power its electrical ...
Sajib Chakraborty, Md. Abdur Razzak
This paper introduces a topology for transformer-less pure sine wave grid-tie inverter (GTI) for photovoltaic (PV) applications. The proposed GTI employs a dual-stage switch mode boost converter, a dual-stage switch mode buck converter, an H-bridge inverter and a T-LCL immittance conversion circuit....