Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia et al.
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lym...
Monika Karmin, Lauri Saag, Mário Vicente, Melissa A. Wilson Sayres et al.
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ...
Luca Pagani, Daniel J. Lawson, Evelyn Jagoda, Alexander Mörseburg et al.
High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for infe...
Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles S. Ebert et al.
BACKGROUND: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics ...
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson et al.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
Ingrid Boas, Carol Farbotko, Helen Adams, Harald Sterly et al.
ForewordIntroduction PART 1: CLIMATE AND CULTURE1. Human Agency, Climate Change and Culture: An Archaeological Perspective, Fekri A. Hassan, University College London2. Climate and Weather Discourse in Anthropology: From Determinism to Uncertain Futures, Nicole Peterson, Columbia University, and Ken...
Israt Jahan, Mohammad Muhit, Denny Hardianto, Francis Laryea et al.
AIM: To describe the epidemiology of cerebral palsy (CP) in children from low- and middle-income countries (LMICs) using data from the Global Low- and Middle-Income Country CP register (GLM-CPR). METHOD: The GLM-CPR is a multi-country initiative that combines and compares data from children with CP ...
Firdausi Qadri, Farhana Khanam, Xinxue Liu, Katherine Theiss-Nyland et al.
BACKGROUND: Typhoid fever remains a major cause of morbidity and mortality in low-income and middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended by WHO for implementation in high-burden countries, but there is little evidence about its ability to protect against clini...
Fred Krüger, Greg Bankoff, Terry Cannon, Benedikt M. Orlowski et al.
Introduction The Editors 1 The Culture of (De-)Constructing Disasters. 1.1 Framing Disasters in the 'Global Village': Cultures of Rationality in Risk, Security, and News Kenneth Hewitt 1.2 Conversations in Catastrophe: Neoliberalism and the cultural construction of disaster risk Anthony Oliver-Smith...
Katerina Hilari, Donna L. Lamping, Sarah C. Smith, Sarah Northcott et al.
BACKGROUND: We previously developed the Stroke and Aphasia Quality of Life scale (SAQOL-39) and tested it with people with chronic aphasia. A scale allowing comparisons of quality of life between people with versus without aphasia post-stroke would be of value to clinicians. OBJECTIVES: To evaluate ...
Laura Vang Rasmussen, Ingo Graß, Zia Mehrabi, Olivia M. Smith et al.
Agricultural simplification continues to expand at the expense of more diverse forms of agriculture. This simplification, for example, in the form of intensively managed monocultures, poses a risk to keeping the world within safe and just Earth system boundaries. Here, we estimated how agricultural ...
Imogen E. Napper, Anju Baroth, Aaron Barrett, Sunanda Bhola et al.
Rivers are key pathways for the transfer of microplastics (MP) to marine environments. However, there are considerable uncertainties about the amount of microplastics transported by rivers to the ocean; this results in inaccuracies in our understanding of microplastic quantity and transport by fresh...
Sarah Kettlewell, Nicola L. Walker, Stuart M. Cobbe, Francis L. Burton et al.
UNLABELLED: Procedures that reduce contraction are used to facilitate optical measurements of membrane potential, but it is unclear to what extent they affect the excitability of the heart. This study has examined the electrophysiological consequences of a range of extracellular [Ca2+] (0.7-2.5 mmol...
Catherine Machalaba, Sarah Elwood, Simona Forcella, Kristine M. Smith et al.
Wild birds play a major role in the evolution, maintenance, and spread of avian influenza viruses. However, surveillance for these viruses in wild birds is sporadic, geographically biased, and often limited to the last outbreak virus. To identify opportunities to optimize wild bird surveillance for ...
Sarah Freed, Benoy Kumar Barman, Mark Dubois, Rica Joy Flor et al.
Rice and fish are preferred foods, critical for healthy and nutritious diets, and provide the foundations of local and national economies across Asia. Although transformations, or “revolutions”, in agriculture and aquaculture over the past half-century have primarily relied upon intensified monocult...
Israt Jahan, Mohammad Muhit, Denny Hardianto, Francis Laryea et al.
BACKGROUND: This study aimed to describe the epidemiology of malnutrition among children with cerebral palsy (CP) in low- and middle-income countries (LMICs). METHODS: Data from children with confirmed CP aged <18 years registered into the Global LMIC CP Register (GLM CPR) from Bangladesh, Indonesia...
Israt Jahan, Tasneem Karim, Manik Chandra Das, Mohammad Muhit et al.
AIM: To determine the mortality rate, immediate cause of death (CoD), and predictors of death in children with cerebral palsy (CP) in rural Bangladesh. METHOD: We carried out a prospective population-based surveillance study of children with CP aged 0 to 18 years registered with the Bangladesh Cereb...
Mahmudul Hassan Al Imam, Israt Jahan, Mohammad Muhit, Denny Hardianto et al.
Background: We assessed the rehabilitation status and predictors of rehabilitation service utilisation among children with cerebral palsy (CP) in selected low- and middle-income countries (LMICs). Methods: Data from the Global LMIC CP Register (GLM-CPR), a multi-country register of children with CP ...
Shona Goldsmith, Hayley Smithers‐Sheedy, Nihad A. Almasri, Guro L. Andersen et al.
AIM: To provide a description of cerebral palsy (CP) registers globally, identify which aim to report on CP epidemiology, and report similarities and differences across topics of importance for the sustainability and collaboration between registers. METHOD: Representatives of all known CP registers ...