Michio Hashimoto, Shahdat Hossain, Toshio Shimada, Kozo Sugioka et al.
Docosahexaenoic acid (C22:6, n-3), a major n-3 fatty acid of the brain, has been implicated in restoration and enhancement of memory-related functions. Because Alzheimer's disease impairs memory, and infusion of amyloid-beta (Abeta) peptide (1-40) into the rat cerebral ventricle reduces learning abi...
Michio Hashimoto, Shahdat Hossain, Abdullah Al Mamun, Kentaro Matsuzaki et al.
Docosahexaenoic acid (DHA, C22:6, ω-3) is a highly polyunsaturated omega-3 fatty acid. It is concentrated in neuronal brain membranes, for which reason it is also referred to as a "brain food". DHA is essential for brain development and function. It plays an important role in improving antioxidant a...
Michio Hashimoto, Shahdat Hossain, H AGDUL, Osamu Shido
We investigated the effects of dietary administration of docosahexaenoic acid (DHA; C22:6n-3) on the levels of amyloid beta (A beta) peptide (1-40) and cholesterol in the nonionic detergent Triton 100 x-insoluble membrane fractions (DIFs) of the cerebral cortex and, also, on learning-related memory ...
Michio Hashimoto, Shahdat Hossain, Toshio Shimada, Osamu Shido
In the present study, we investigated the relationship between the docosahexaenoic acid (DHA)-induced protection of learning deficit of amyloid beta(1-40)-infused Alzheimer's disease (AD) model rats and changes in synaptosomal plasma membrane fluidity of the cerebral cortex. Synaptosomal membrane la...
Shahdat Hossain, Michio Hashimoto, Emran Kabir Choudhury, Nuhu Alam et al.
1. The effects of edible oyster mushroom Pleurotus ostreatus on plasma and liver lipid profiles and on the plasma total anti-oxidant status were estimated in hyper- and normocholesterolaemic Long Evans rats. 2. The feeding of 5% powder of the fruiting bodies of P. ostreatus mushrooms to hypercholest...
Jingcheng Dai, Aijun Dong, Guoxi Xiong, Yaqi Liu et al.
In this study, a series of bacteria capable of degrading starch and cellulose were isolated from the aging flue-cured tobacco leaves. Remarkably, there was a thermophilic bacterium Bacillus subtilis ZIM3 which can simultaneously degrade both starch and cellulose at a wide range of temperature and pH...
Michio Hashimoto, Shahdat Hossain
Docosahexaenoic acid (DHA, C22:6 n-3), the most abundant n-3 polyunsaturated fatty acid in the brain, is essential for brain growth and development. Recent evidence has indicated the potential health benefits of DHA for managing Alzheimer's disease (AD). For example, dietary administration of DHA co...
Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdullah Al Mamun et al.
We investigated whether a highly purified eicosapentaenoic acid (EPA) and a concentrated n-3 fatty acid formulation (prescription TAK-085) containing EPA and docosahexaenoic acid (DHA) ethyl ester could improve the learning ability of aged rats and whether this specific outcome had any relation with...
Shahdat Hossain, Sujan Bhowmick, Sabrin Jahan, Liza Rozario et al.
The presence of lead (Pb) in fetal brain may affect brain development-related proteins. We studied whether gestational/lactational Pb-exposure affects oxidative stress, proinflammatory response, apoptosis and levels of brain development/cognition-related proteins, including presynaptic synaptosome-a...
Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura et al.
We have previously reported that dietary docosahexaenoic acid (DHA) improves and/or protects against impairment of cognition ability in amyloid beta(1-40) (Abeta(1-40))-infused Alzheimer's disease (AD)-model rats. Here, after the administration of DHA to AD model rats for 12 weeks, the levels of Abe...
Shahdat Hossain, Rashed Ahmed, Sujan Bhowmick, Abdullah Al Mamun et al.
The high mortality rate in Bangladesh is related to poverty, which results in protein malnutrition, essential fatty acid deficiency and lacks in adequate vitamins, minerals and calorie. Exploring new food items with improved dietary nutrition factors may, therefore, help to decrease the mortality ra...
Shahdat Hossain, Michio Hashimoto, Masanori Katakura, Koji Miwa et al.
The mechanism of the effect of docosahexaenoic acid (DHA; C22:6, n-3), one of the essential brain nutrients, on in vitro fibrillation of amyloid beta (Abeta(1-42)), Abeta(1-42)-oligomers and its toxicity imparted to SH-S5Y5 cells was studied with the use of thioflavin T fluorospectroscopy, laser con...
Michio Hashimoto, Setsushi Kato, Yoko Tanabe, Masanori Katakura et al.
AIM: We examined the effects of the administration of docosahexaenoic acid (DHA)-enriched meals on cognitive function in the oldest elderly with cognitive impairment, such as dementia, living in nursing homes, and on the improvement in caregiver burden at aging agencies. METHODS: Participants in eld...
Michio Hashimoto, Shahdat Hossain
Fatty acid constitutes the foundation cell membranes, provides metabolic energy, affects functions of membrane-bound enzymes/receptors, conducts signaling cascades, and helps in learning-related memory cognition in mammals, including humans. Structurally, the fatty acids are of two kinds: saturated ...
Michio Hashimoto, Shahdat Hossain, Osamu Shido
To determine the differential effects of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid on platelet membrane fluidity under hypercholesterolemic conditions. DHA and EPA were orally administered (300 mg/kg body weight(.)day) to hypercholesterolemic rats for 12 weeks. Membrane fluidity, evaluat...