Plabon Kumar Das, Suja Pillai, Md. Abdur Rakib, Jahan Ara Khanam et al.
In embryonic development and throughout life, there are some cells can exhibit phenotypic plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In normal development, plasticity is highly regulated whereas cancer cells re-activate this dynamic ability for...
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K. Lam et al.
Estrogens have been implicated in the pathogenesis of various cancer types, including colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular signaling cascades followed by binding to estrogen, resulting in important changes in cellular behaviors. The nuclear estrog...
Farhadul Islam, Vinod Gopalan, Suja Pillai, Cu‐Tai Lu et al.
The present study aims to examine promoter methylation status of FAM134B in a large cohort of patients with colorectal adenocarcinomas. The clinical significances and correlations of FAM134B promoter methylation with its expression are also analysed. Methylation-specific high-resolution melt-curve a...
Plabon Kumar Das, Tasnim Zahan, Md. Abdur Rakib, Jahan Ara Khanam et al.
BACKGROUND: Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence. METHODS: A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google s...
Plabon Kumar Das, Mst. Ayesha Siddika, Saharia Yeasmin Asha, Suraiya Aktar et al.
Reactivation of the stem cell programme in breast cancer is significantly associated with persistent cancer progression and therapeutic failure. Breast cancer stem cells (BCSCs) are involved in the process of breast cancer initiation, metastasis and cancer relapse. Among the various important cues f...
Vinod Gopalan, Faeza Ebrahimi, Farhadul Islam, Jelena Vider et al.
Objectives: In this study, we aimed to investigate the expression pattern, clinicopathological significance and tumour suppressive properties of miR‐15a in patients with colorectal carcinomas. Methods: Tissue samples from 87 patients with primary colorectal carcinomas, 50 matched metastatic lymph no...
Plabon Kumar Das, Md. Abdur Rakib, Jahan Ara Khanam, Suja Pillai et al.
BACKGROUND: Breast cancer remains to be one of the deadliest forms of cancers, owing to the drug resistance and tumor relapse caused by breast cancer stem cells (BCSCs) despite notable advancements in radio-chemotherapies. OBJECTIVES: To find out novel therapeutics against breast cancer stem cells b...
Farhadul Islam, Suja Pillai, Vinod Gopalan, Alfred K. Lam
Endothelial PAS domain-containing protein 1 (EPAS1) is an oxygen-sensitive component of the hypoxia-inducible factors (HIFs) having reported implications in many cancers by inducing a pseudo-hypoxic microenvironment. However, the molecular dysregulation and clinical significance of EPAS1 has never b...
Plabon Kumar Das, Ayesha Siddika, K M Rashel, Abdul Auwal et al.
INTRODUCTION: Long noncoding RNAs (lncRNAs) play crucial roles in regulating various hallmarks in cancers. Triple-negative (Estrogen receptor, ER; Human epidermal growth factor receptor 2, HER2; Progesterone receptor, PR) breast cancer (TNBC) is the most aggressive form of breast cancers with a poor...
Farhadul Islam, Vinod Gopalan, Simon Law, Alfred K. Lam et al.
Endothelial PAS domain-containing protein 1 (EPAS1) is an angiogenic factor and its implications have been reported in many cancers but not in esophageal squamous cell carcinoma (ESCC). Herein, we aim to examine the genetic and molecular alterations, clinical implications, and functional roles of EP...
Farhadul Islam, Vinod Gopalan, Cu‐Tai Lu, Suja Pillai et al.
Endothelial PAS domain-containing protein 1 (EPAS1) has implications in many cancers. However, the molecular behaviours, functional roles and mutational status of EPAS1 have never been studied in colorectal carcinoma (CRC). The study aims to examine the genetic alterations and functional roles of EP...
Ichiro Abe, Farhadul Islam, Chung Yau Lo, Victor Liew et al.
Vascular endothelial growth factor (VEGF) is important in pathogenesis of different cancers. The aim of this study is to investigate the relationships between different VEGFs and clinicopathological factors in patients with phaeochromocytomas. Twenty patients (10 men; 10 women) with non-hereditary, ...
Farhadul Islam, Ichiro Abe, Suja Pillai, Robert A. Smith et al.
In this Research Topic, we have collected recent developments in research into Pheochromocytomas and Paragangliomas (PPGLs), highlighting their molecular mechanisms, clinical manifestations, and improved therapeutic management.\n\nPPGLs are the primary types of neuroendocrine tumors, and are relativ...
Ichiro Abe, Farhadul Islam, Suja Pillai
PPGLs are relatively rare neuroendocrine tumors derived from chromaffin cells in the adrenal medulla and/or autonomic nervous system ganglia. Their clinical importance, including various associated complications, is due to catecholamine excess (1,2). Moreover, PPGLs could lead to pheochromocytoma mu...
Plabon Kumar Das, Ayesha Siddika, Suja Pillai, Farhadul Islam