Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae Hoon Kim et al.
), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties ...
Hyun‐Cheol Lee, Eun‐Seo Lee, Md Bashir Uddin, Tae‐Hwan Kim et al.
ARSs are essential enzymes in translation that link specific amino acids to their cognate tRNAs. In higher eukaryotes, some ARSs possess additional, noncanonical functions in the regulation of cell metabolism. Here, we report a novel noncanonical function of WRS in antiviral defense. WRS is rapidly ...
Mohammed Yousuf Elahi Chowdhury, Rui Li, Jae Hoon Kim, Min-Eun Park et al.
To develop a safe and effective mucosal vaccine against pathogenic influenza viruses, we constructed recombinant Lactobacillus casei strains that express conserved matrix protein 2 with (pgsA-CTA1-sM2/L. casei) or without (pgsA-sM2/L. casei) cholera toxin subunit A1 (CTA1) on the surface. The surfac...
Rui Li, Mohammed Yousuf Elahi Chowdhury, Jae‐Hoon Kim, Tae-Hwan Kim et al.
The development of a universal influenza vaccine that provides broad cross protection against existing and unforeseen influenza viruses is a critical challenge. In this study, we constructed and expressed conserved sM2 and HA2 influenza antigens with cholera toxin subunit A1 (CTA1) on the surface of...
Jae Hoon Kim, Prasanna Weeratunga, Myun Soo Kim, Chamilani Nikapitiya et al.
BACKGROUND: Cortex Phellodendri (C. Phellodendri), the dried trunk bark of Phellodendron amurense Ruprecht, has been known as a traditional herbal medicine, showing several bioactivities. However, antiviral activity of C. Phellodendri aqueous extract (CP) not reported in detail, particularly aiming ...
Mohammed Yousuf Elahi Chowdhury, Tae-Hwan Kim, Md Bashir Uddin, Jae Hoon Kim et al.
To develop a safe and effective mucosal vaccine that broad cross protection against seasonal or emerging influenza A viruses, we generated a mucosal influenza vaccine system combining the highly conserved matrix protein-2 (sM2), fusion peptide of hemagglutinin (HA 2 ), the well-known mucosal adjuvan...
Md. Akil Hossain, Seung‐Jin Lee, Jiyong Park, Md. Ahsanur Reza et al.
Ethnopharmacological relevance Nymphaea tetragona is a widely distributed ornamental species with ethnomedicinal uses in the treatment of diarrhea, dysentery, eruptive fevers, and infections. The anti-infectious activities of this herb have already been assessed to clarify its traditional use as a m...
Jaehoon Kim, Min-Eun Park, Chamilani Nikapitiya, Tae‐Hwan Kim et al.
FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1gt/gt mice, which defic...
Jaehoon Kim, Tae‐Hwan Kim, Hyun‐Cheol Lee, Chamilani Nikapitiya et al.
ABSTRACT Rubicon is part of a Beclin-1-Vps34-containing autophagy complex. Rubicon induces antimicrobial responses upon Toll-like receptor (TLR) stimulation and functions as a feedback inhibitor to prevent unbalanced proinflammatory responses depending on dectin-1 signaling. However, the role played...
Bok‐Rye Lee, Rashed Zaman, Van Hien La, Dong‐Won Bae et al.
The leaf senescence process is characterized by the degradation of macromolecules in mature leaves and the remobilization of degradation products via phloem transport. The phytohormone ethylene mediates leaf senescence. This study aimed to investigate the ethephon-induced ethylene effects on starch ...
Melbourne Rio Talactac, Mohammed Yousuf Elahi Chowdhury, Min-Eun Park, Prasanna Weeratunga et al.
In order to identify new potential antiviral agents, recent studies have advocated thorough testing of herbal medicines or natural substances that are traditionally used to prevent viral infections. Antiviral activities and the mechanism of action of the total aqueous extract preparation of KIOM-C, ...
Jaehoon Kim, Jieun Yoon, Chamilani Nikapitiya, Tae‐Hwan Kim et al.
Small heterodimer partner (SHP) is an orphan nuclear receptor that acts as a transcriptional co-repressor by interacting with nuclear receptors and transcription factors. Although SHP plays a negative regulatory function in various signaling pathways, its role in virus infection has not been studied...
Bok‐Rye Lee, Rashed Zaman, Van Hien La, Sang‐Hyun Park et al.
To investigate the regulatory role of ethylene in the source-sink relationship for nitrogen remobilization, short-term effects of treatment with different concentrations (0, 25, 50, and 75 ppm) of ethephon (2-chloroethylphosphonic acid, an ethylene inducing agent) for 10 days (EXP 1) and long-term e...