Silvia Schnyder‐Candrian, Valérie Quesniaux, Franco Di Padova, Isabelle Maillet et al.
Abstract The administration of endotoxins from Gram-negative bacteria induces manifestations reminding of acute respiratory distress syndrome. p38 MAPKs have been implicated in this pathology. In this study, we show that the specific p38 α,β MAPK inhibitor, compound 37, prevents LPS-induced bronchoc...
Nicolas Noulin, Valérie Quesniaux, Silvia Schnyder‐Candrian, Bruno Schnyder et al.
Inhaled endotoxin induces an inflammatory response that contributes to the development and severity of asthma and other forms of airway disease. Here, we show that inhaled endotoxin-induced acute bronchoconstriction, TNF, IL-12p40, and KC production, protein leak, and neutrophil recruitment in the l...