Lei Qiao, Jing Ma, Zihao Zhang, Wenhai Sui et al.
Rationale: The NLRP3 (NLR [NOD-like receptor] family, pyrin domain containing 3) inflammasome is an important driver of atherosclerosis. Our previous study shows that chaperone-mediated autophagy (CMA), one of the main lysosomal degradative process, has a regulatory role in lipid metabolism of macro...
Meng Zhang, Wenhai Sui, Yanqiu Xing, Jing Cheng et al.
The rennin-angiotensin-aldosterone system (RAAS) plays a critical role in the pathogenesis of diabetic cardiomyopathy, but the role of a member of RAAS, angiotensin IV (Ang IV), in this disease and its underlying mechanism are unclear. This study was aimed to clarify the effects of Ang IV and its do...
Fei Xue, Jing Cheng, Yan Liu, Cheng Cheng et al.
Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and metalloprotease protein-17 (ADAM17). However, whether ADAM17 plays a role in the pathogenesis and intervention of DCM is obscur...
Linlin Meng, Yue Lu, Xinlu Wang, Cheng Cheng et al.
Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM). Previous studies demonstrated the cardioprotective effects of natriuretic peptides. However, the effects of natriuretic peptide receptor C (NPRC) on cardiac fibrosis in DCM remains unknown. Here, we observed that ...
Jie Zhang, Lei Cao, Xiaohong Wang, Qian Li et al.
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive renal disease (HRD). However, the signaling mechanisms underlying their induction are poorly understood, and the role of tripartite motif-containing protein 31 (TRIM31), an E3 ubiquitin ligase, in HRD rem...
Cheng Cheng, Jie Zhang, Xiaodong Li, Fei Xue et al.
Abstract Previous studies suggested a beneficial effect of natriuretic peptides in animal models of cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the pathogenesis of atherosclerosis (AS) remains unknown. This study was designed to test the hypothesis that NPRC may ...
Weijie Wu, Wenhai Sui, Sizhe Chen, Ziheng Guo et al.
mice exacerbated atherosclerosis. Whole-genome expression profiling discovered that CX3CL1 chemokine was the most upregulated gene in the insulin-stimulated arterial endothelial cells. Specific deletion of a CX3CL1 receptor, Cx3cr1 gene, in monocytes/macrophages completely abrogated the APM-exacerba...
Xiaoting Sun, Wenhai Sui, Zepeng Mu, Sisi Xie et al.
Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain largel...
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren et al.
Innate immunity is the first line to defend against pathogenic microorganisms, and Toll-like receptor (TLR)-mediated inflammatory responses are an essential component of innate immunity. However, the regulatory mechanisms of TLRs in innate immunity remain unperfected. We found that the expression of...
Chenghu Guo, Wei Ji, Wei Yang, Qiming Deng et al.
Myocardial infarction (MI) remains the leading cause of death worldwide. Cardiac fibroblasts (CFs) are abundant in the heart and are responsible for cardiac repair post-MI. NF-κB-repressing factor (NKRF) plays a significant role in the transcriptional inhibition of various specific genes. However, t...
Kunsheng Zhao, Yun Zhang, Wenhai Sui
At present, the association between circulating selenium and stroke is still in dispute. Thus, this study aimed to ascertain the association with a larger sample size than the previous study, based on the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. In total, 13755 ad...
Cheng Cheng, Fei Xue, Wenhai Sui, Linlin Meng et al.
Abstract The inflammation of adipose tissue is one of the most common secondary pathological changes in atherosclerosis, which in turn influences the process of atherosclerosis. Natriuretic peptides have been revealed important effect in regulating adipose metabolism. However, the relationship betwe...
Jianlin Zhang, Yu Cao, Ruiqing Ren, Wenhai Sui et al.
Abstract Abdominal aortic aneurysm (AAA) is a life‐threatening vascular disease but effective drugs for treatment of AAA are still lacking. Recently, erythropoietin (EPO) is reported to induce AAA formation in apolipoprotein‐E knock out (ApoE −/− ) mice but an effective antagonist is unknown. In thi...
Wenhai Zhang, Jiyao Wang, Wei Xu
In order to achieve fast and convenient design of fully flexible actuators suitable for special gripping modes, a soft actuator for gripper based on pneumatic metastructure is proposed inspired by the pulvinus of Mimosa pudica. The hyperelastic material is used to fabricate the soft actuators. Finit...
Linlin Meng, Yue Lu, Xinlu Wang, Wenhai Sui et al.
CD4 + CD25 + regulatory T cells (Tregs) have been shown to protect against abdominal aortic aneurysm (AAA) progression. Statins have immunomodulatory properties, and their effect on AAA partly depends on immune-related mechanisms. In this study, we aimed to explore whether there is an association be...