Ying Bai, Yuan Zhang, Bing Han, Li Yang et al.
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge...
Bin Li, Xi Wen, Ying Bai, Xue Liu et al.
Abstract Vascular repair is considered a key restorative measure to improve long-term outcomes after ischemic stroke. N 6 -methyladenosine (m 6 A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, whether circular RNA SCMH1 (circSCMH1) pro...
Minsheng You, Fushi Ke, Shijun You, Zhangyan Wu et al.
The diamondback moth, Plutella xylostella is a cosmopolitan pest that has evolved resistance to all classes of insecticide, and costs the world economy an estimated US $4-5 billion annually. We analyse patterns of variation among 532 P. xylostella genomes, representing a worldwide sample of 114 popu...
Xueli Hu, Zhang Zhi, Peng Lu, Yuanhang Zhou et al.
Without light at night, the system for photocatalytic degradation of refractory organic pollutants in aquatic environments based on free radicals will fall into a dormant state. Hence, a round-the-clock photocatalyst (CCN@SMSED) was prepared by in situ growth of cyanide-deficient g-C3N4 on the surfa...
Tianshu Liu, Yuxian Bai, Xiaoyan Lin, Wěi Li et al.
First-line chemotherapy for advanced/metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric/gastroesophageal junction cancer (GC/GEJC) has poor median overall survival (OS; <1 year). We report efficacy and safety results from Chinese patients in the phase III global CheckMate 64...
Yanpeng Jia, Yi Zhang, Wenjun Zhan, Yu Wang et al.
Abstract Ischemic stroke is a major cause of death and disability worldwide. The poor drug delivery to cerebral ischemic regions remains a challenging issue for ischemic stroke treatment. Curcumin (Cur) and edaravone (EDV) show remarkable therapeutic effects on ischemic stroke. However, the short ha...
Ying Bai, Yang Cai, Di Chang, Daxing Li et al.
Depression stands as a prominent contributor to global disability, entailing an elevated risk of suicide. Substantial evidence supports the notion that immune dysregulation may play a role in the development of depression and impede responses to antidepressant treatments. Immune dysregulation may ca...
Ziwei Huang, Wei Deng, Zhengwei Zhang, Bei Zhao et al.
Abstract The controlled etching of 2D transition metal dichalcogenides (2D‐TMDs) is critical to understanding the growth mechanisms of 2D materials and patterning 2D materials but remains a major comprehensive challenge. Here, a rational strategy to control the terminal atoms of 2D‐TMDs etched holes...
Ying Bai, Susan P. Montgomery, Kelly Sheff, Manjur A. Chowdhury et al.
Ecological and bacteriologic observations of small mammals captured in Dhaka, Bangladesh, indicated that Bartonella infections occurred in high prevalence among lesser bandicoot rats (Bandicota bengalensis), black rats (Rattus rattus), and house shrews (Suncus murinus). Sequence analysis of the citr...
Ye Sun, Tianyu Li, Hua Chen, Kun Zhang et al.
Glutathione peroxidase (GPX) is one of the most crucial antioxidant enzymes in a variety of organisms. Here we described a new strategy for generating a novel GPX mimic by combination of a phage-displayed random 15-mer peptide library followed by computer-aided rational design and chemical mutation....
Jin Bai, Lei Zhang, Ying Qian
In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy of A549 cells. In the strategy of designing SBOP-Lyso, S atom in thiophene as well as heavy atom I were introduced to promote IS...
Muhammad Tahir Lakhiar, Yu Bai, Leong Sing Wong, Suvash Chandra Paul et al.
Longfei Du, Kai Shen, Ying Bai, Jie Chao et al.
Nod-like Receptor Protein 3 (NLRP3) inflammasome activation is known to lead to microglia-mediated neuroinflammation. Methamphetamine is known to induce microglial activation. However, whether NLRP3 inflammasome activation contributes to the microglial activation induced by methamphetamine remains e...
Labib Imran Faruque, Rashid Zaman, Emily S. Gurley, Robert F. Massung et al.
BACKGROUND: We conducted a study to identify Rickettsia, Coxiella, Leptospira, Bartonella, and Chikungunya virus infections among febrile patients presenting at hospitals in Bangladesh. METHODS: We collected blood samples from patients at six tertiary hospitals from December 2008 to November 2009 an...
Yuan Zhang, Ling Shen, Jian Xie, Lu Li et al.
BACKGROUND As a leading cause of long-term disability, ischemic stroke urgently needs further research and drug development. Pushen capsule (Pushen) has been commonly applied in clinical treatment for relieving headaches, dizziness, and numbness. However, the effects of Pushen on ischemic stroke hav...