Benedikt Ley, Nick Luter, Fe Esperanza Espino, Angela Devine et al.
The only currently available drug that effectively removes malaria hypnozoites from the human host is primaquine. The use of 8-aminoquinolines is hampered by haemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. Recently a number of qualitative and a quantitative...
Rashan Haniffa, Yoel Lubell, Ben S. Cooper, Sanjib Mohanty et al.
OBJECTIVE: To assess the impact on ICU performance of a modular training program in three resource-limited general adult ICUs in India, Bangladesh, and Nepal. METHOD: A modular ICU training programme was evaluated using performance indicators from June 2009 to June 2012 using an interrupted time ser...
Arjun Chandna, Nan Shwe Nwe Htun, Thomas J. Peto, Marco Liverani et al.
<ns3:p>In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provi...
Yoel Lubell, Shunmay Yeung, Arjen M. Dondorp, Nicholas Day et al.
OBJECTIVE: To explore the cost-effectiveness of artesunate against quinine based principally on the findings of a large multi-centre trial carried out in Southeast Asia. METHODS: Trial data were used to compare mortality of patients with severe malaria, treated with either artesunate or quinine. Thi...
Arjun Chandna, Rusheng Chew, Nan Shwe Nwe Htun, Thomas J. Peto et al.
<ns3:p>In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provi...
Arjun Chandna, Endashaw M. Aderie, Riris Andono Ahmad, Eggi Arguni et al.
INTRODUCTION: In rural and difficult-to-access settings, early and accurate recognition of febrile children at risk of progressing to serious illness could contribute to improved patient outcomes and better resource allocation. This study aims to develop a prognostic clinical prediction tool to assi...
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal et al.
<ns3:p> <ns3:bold>Background:</ns3:bold> Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day course of a single oral antimicrobial such a...
Yin Mo, Ying Ding, Yang Cao, Jill Hopkins et al.
<ns3:p> <ns3:bold>Background</ns3:bold> : <ns3:bold/> Antimicrobial resistance surveillance is essential for empiric antibiotic prescribing, infection prevention and control policies and to drive novel antibiotic discovery. However, most existing surveillance systems are isolate-based without suppor...
Yoel Lubell
The decrease in malaria burden in the past decade has coincided with a greater than 15-times increase in international spending on malaria control1WHOWorld Malaria Report 2013. World Health Organization, Geneva2013Google Scholar and a shift in approach towards a goal of local elimination in many end...
Rusheng Chew, Chris Painter, Wirichada Pan–ngum, Nicholas P. J. Day et al.
Background: Multiplex lateral flow rapid diagnostic tests (LF-RDTs) may aid management of patients with acute non-malarial febrile illness (NMFI) in rural south and southeast Asia. We aimed to evaluate the cost-effectiveness in Cambodia and Bangladesh of a putative, as-yet-undeveloped LF-RDT capable...
Nan Shwe Nwe Htun, Carlo Perrone, Aung Pyae Phyo, Aninda Sen et al.
INTRODUCTION: Causes of deaths often go unrecorded in lower income countries, yet this information is critical. Verbal autopsy is a questionnaire interview with a family member or caregiver to elicit the symptoms and circumstances preceding a death and assign a probable cause. The social and cultura...
Meiwen Zhang, Nan Shwe Nwe Htun, Shayla Islam, Aninda Sen et al.
INTRODUCTION: In low-income and middle-income countries in Southeast Asia, the burden of diseases among rural population remains poorly understood, posing a challenge for effective healthcare prioritisation and resource allocation. Addressing this knowledge gap, the South and Southeast Asia Communit...
Arjun Chandna, Constantinos Koshiaris, Raman Mahajan, Riris Andono Ahmad et al.
BACKGROUND: Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activation markers stratify risk in common childhood infections. We aimed to assess their use in children with febrile illness presenting from rural...
Meiwen Zhang, Hannah Kozlowski, Rusheng Chew, Nan Shwe Nwe Htun et al.
BACKGROUND: Southeast Asia is undergoing an epidemiological transition with non-communicable illnesses becoming increasingly important, yet infectious diseases (tuberculosis, HIV, hepatitis B, malaria) remain widely prevalent in some populations, while emerging and zoonotic diseases threaten. There ...
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal et al.
<ns4:p> <ns4:bold>Background:</ns4:bold> Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day course of a single oral antimicrobial such a...