Journal ArticleOpen Access
Zinc Influences Innate Immune Responses in Children with Enterotoxigenic Escherichia coli-Induced Diarrhea
Author Affiliations
International Centre for Diarrhoeal Disease Research, University of Dhaka, University of Maryland, Baltimore, University of British Columbia
Published InJournal of Nutrition
Year2010
Citations73
Abstract
Information is limited on the effect of zinc on immune responses in children with diarrhea due to enterotoxigenic Escherichia coli (ETEC), the most common bacterial pathogen in children. We studied the immunological effect of zinc treatment (20 mg/d) and supplementation (10 mg/d) in children with diarrhea due to ETEC. A total of 148 children aged 6-24 mo were followed up for 9 mo after a 10-d zinc treatment (ZT; n = 74) or a 10-d zinc treatment plus 3-mo supplementation (ZT+S; n = 74), as well as 50 children with ETEC-induced diarrhea that were not treated with zinc (UT). Fifty control children (HC) of the same age group from the same location were also studied. Serum zinc concentrations were higher…
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