James Perry, Normand Laperrière, Christopher J. O’Callaghan, Alba A. Brandes et al.
BACKGROUND: Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter c...
Gerald W. Marsa, Don R. Goffinet, Lucien J. Rubinstein, Malcolm A. Bagshaw
Curative radiotherapy was attempted in treating 256 patients with unresected or partially excised gliomas of the brain and spinal cord. Survival decreased with increasing age, reflecting the different incidences of tumor types in various age groups. Actuarial 5-year survival ranged from 85% for cere...
Andreas A. Argyriou, Susanna B. Park, Badrul Islam, Stefano Tamburin et al.
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common dose-limiting side effect of several anticancer medications. CIPN may involve multiple areas of the peripheral nervous system from the autonomic and dorsal root ganglia (DRG) to the axon and any peripheral nerve fibre type. Large diame...
Rajesh Balakrishnan, Rokeya Porag, Dewan Shamsul Asif, A. M. Rejaus Satter et al.
Primary CNS melanomas are rare and they constitute about 1% of all cases of melanomas and 0.07% of all brain tumors. These tumors are aggressive in nature and may metastasise to other organs. Till date less than 25 cases have been reported in the literature. The primary treatment for local intrapare...
Nahida Sultana, Chao Sun, Takanori Katsube, Bing Wang
Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is,...
Md Rashedunnabi Akanda, Eun‐Jung Ahn, Yeong Jin Kim, S M Abdus Salam et al.
Our results suggest that high expression of CAF-related biomarkers, particularly PDGFR-β and α-SMA, is associated with poor prognosis and recurrence in patients with BM. With the elucidation of the role and origins of CAF in the tumor microenvironment, CAF can be a new imperative target for BM immun...
Rupa Guha, Binbin Yue, Jianping Dong, Aditi Banerjee et al.
Triple negative breast cancer (TNBC) is characterized by invasiveness and short survival. Identifying novel TNBC-targeted therapies, to potentiate standard of care (SOC) therapy, is an unmet need. Progranulin (PGRN/GP88) is a biological driver of tumorigenesis, survival, and drug resistance in sever...
Mohammed Maan Al‐Salihi, Maryam Sabah Al-Jebur, Iván David Lozada-Martínez, Md Moshiur Rahman et al.
ABSTRACT Introduction and importance: Brain metastasis of prostatic cancer is highly a rare condition. Its intracranial metastatic process and presentation are poorly understood and limited to case reports, making it challenging to detect and diagnose. We aim to highlight the rare case, brain metast...
Katalin Fábián, Márton Gyulai, József Furák, Péter Várallyay et al.
BACKGROUND: Brain metastasis of lung cancer adversely affects overall survival (OS) and quality of life, while peritumoral brain edema is responsible for life-threatening complications. METHODS: We retrospectively analyzed the clinicopathological and cerebral radiological data of 575 consecutive lun...
Kazi T. Afrin, Salahuddin Ahmad
Abstract Aim: The objective of this study has been to identify monitor unit (MU) and treatment time variations, volume coverage dissimilarity among 3D conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans for he...
Md Rashedunnabi Akanda, Eun‐Jung Ahn, Yeong Jin Kim, S M Abdus Salam et al.
BACKGROUND: Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investigated the relationship between the expression of stromal CA...
Patrizia Olmi, C. Fallai, Federica Rossi, S. Crispino et al.
Nazmin Ahmed, M. Hossain, Raju Ahmed, Md Mahmud Abbasi et al.
Background: The use of fluorescein sodium (FS) as a surgical adjunct in glioblastoma resection has shown promise in improving tumor visualization and resection outcomes. This study aimed to evaluate the safety, efficacy, and side effects of FS-aided resection in patients with glioblastoma. Methods: ...
Garima Garima, Sharad Thanvi, Anurag K. Singh, Vijay Verma
Background Glioblastoma is the most frequent and the most aggressive primary malignant brain tumor in adults. Standard treatment includes surgical removal of the tumor followed by concomitant chemotherapy and radiotherapy. Temozolomide, an oral alkylating agent, is currently the most commonly used c...
Narjisse Aichouni, Hamid Ziani, Imane Kamaoui, Siham Nasri et al.
Choroidal metastasis is the most common malignant intraocular tumor. Its diagnosis in a patient with known lung cancer is usually easy. However, without any context of already known cancer, further elements are needed to guide the diagnosis. We report the case of a 47-year-old patient with a history...