P Maxwell, Ryan S. Gallagher, Angela Seaton, Catherine Wilson et al.
Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more malignant phenotype. The expression of interleukin-8 (IL-8) plays an important role in the tumorigenesis and metastasis of solid tumors including prostate cancer. Recently, we detected elevated expression ...
B. S. Soler Federsppiel, Ian G. Melhado, Alessandra M.V. Duncan, Allen Delaney et al.
A family of proinflammatory cytokines sharing several structural features has been described and includes, for example, interleukin-8, monocyte chemoattractant protein-1, and melanocyte growth stimulatory activity. Recently, the receptors for interleukin-8 have been isolated and found to belong to t...
Amanda M. Burkhardt, Kenneth P. Tai, Juan P. Flores-Guiterrez, Natalia Vilches‐Cisneros et al.
The mucosal immune network is a crucial barrier preventing pathogens from entering the body. The network of immune cells that mediates the defensive mechanisms in the mucosa is likely shaped by chemokines, which attract a wide range of immune cells to specific sites of the body. Chemokines have been...
Taku Nedachi, Hiroyasu Hatakeyama, Tatsuyoshi Kono, Masaaki Sato et al.
Physical exercise triggers the release of several cytokines/chemokines from working skeletal muscles, but the underlying mechanism(s) by which skeletal muscles decipher and respond to highly complex contractile stimuli remains largely unknown. In an effort to investigate the regulatory mechanisms of...
Marianne Pavel, Gerda Hassler, Ulrich Baum, Eckhart G. Hahn et al.
OBJECTIVE: The growth behaviour of well-differentiated neuroendocrine carcinomas of the gastro-entero-pancreatic system varies greatly and parameters predicting their prognosis are lacking. The aim of our study was to investigate whether tumour growth could be correlated with the release of proangio...
Yafa Naim Abu Nabah, Mercedes Losada, Rossana Estellés, Teresa Mateo et al.
OBJECTIVE: Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II-induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved. METHODS AND RESULTS: Ang-II (1 nmol/L, i.p. in rats) induced CXC and CC che...
Nuzhat N. Kabir, Jianmin Sun, Lars Rönnstrand, Julhash U. Kazi
The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and ...
Mohammad Sayem, Yusuke Tomita, Akira Yuno, Masatoshi Hirayama et al.
T-cell responses were observed in 14 of 20 HCC patients vaccinated with GPC3-SPs. Repeated vaccinations enhanced GPC3-LP-specific responses in 8 of 13 patients with HCC. Moreover, the presence of the specific Th cell was correlated with prolonged overall survival (OS). GPC3-LPs can be useful for can...
Julio Santiago, José Luis Hernández-Cruz, María Manjarrez-zavala, R. Montes‐Vizuet et al.
Macrophages play a crucial role in respiratory viral infections. However, the mechanisms by which these cells are recruited locally are not fully understood. The current authors studied the role of the chemokines monocyte chemotactic protein (MCP)-1, -2, -3 and -4 on monocyte/macrophage recruitment ...
Md. Abu Horaira, Md. Ariful Islam, Md. Kaderi Kibria, Md. Jahangir Alam et al.
BACKGROUND: Detection of appropriate receptor proteins and drug agents are equally important in the case of drug discovery and development for any disease. In this study, an attempt was made to explore colorectal cancer (CRC) causing molecular signatures as receptors and drug agents as inhibitors by...
Anamika Datta, Fatema Tuz Zahora, Md. Abdul Aziz, Mohammad Sarowar Uddin et al.
OBJECTIVE Cervical cancer is one of the most destructive diseases among females worldwide, especially in developing countries. Interleukin-10 (IL10) is a multifunctional cytokine, and polymorphisms in the IL10 gene have been identified in multiple malignancies. However, no prior studies were conduct...
Md. Rafiqul Islam Khan, Junsuke Uwada, Takashi Yazawa, Tariqul Islam et al.
Impaired intestinal barrier function is one of the critical issues in inflammatory bowel diseases. The aim of this study is to investigate muscarinic cholinoceptor (mAChR)-mediated signaling for the amelioration of cytokine-induced barrier dysfunction in intestinal epithelium. Rat colon challenged w...
Hou‐Qun Ying, Jie Wang, Xueren Gao
Associations between CCL5-403, CCR5-59029, and Delta32 polymorphisms and cancer risk are inconclusive. To derive a more precise estimation of the association, we performed a meta-analysis by searching PubMed, EMBASE, Google scholar, and WanFang databases. A total of 20 eligible articles with 39 stud...
Fangyu Wang, Tianyuan Zhang, Jin-Xian LUO, Guoan He et al.
Human CC chemokine receptor (CCR) 5 is a G protein-coupled receptor involved in a broad range of human diseases that mediates HIV-1 viral entry into cells. Certain small molecule receptor antagonists to CCR5 have been useful in therapy for these diseases. In this study, CCR5-expressing CHO cells (CH...
Jin‐Young Choi, Jin Hyoung Kim, Ferdaus Mohd Altaf Hossain, Erdenebelig Uyangaa et al.
A coordinated host immune response mediated via chemokine network plays a crucial role in boosting defense mechanisms against pathogenic infections. The speed of Ag presentation and delivery by CD11c+ dendritic cells (DCs) to cognate T cells in lymphoid tissues may decide the pathological severity o...