Bo Yan, Peidong Han, Lifeng Pan, Wei Lü et al.
During inflammation, the proper inflammatory infiltration of neutrophils is crucial for the host to fight against infections and remove damaged cells and detrimental substances. IL-1β and NADPH oxidase-mediated reactive oxygen species (ROS) have been implicated to play important roles in this proces...
Lauri Miller, Scott H. Kurtzman, Kathleen Anderson, Yanping Wang et al.
We hypothesize that interleukin-1α, β, and receptor antagonist (IL-1α, IL-1β, and IL-1ra, respectively) are present and tumor cell associated in human breast cancer (HBC). We believe the levels of these cytokines in breast tumor homogenates relate to other known prognosticators of patient survival (...
Ashok Choudhury, Manoj Kumar, Barjesh Chander Sharma, Rakhi Maiwall et al.
BACKGROUND AND AIM: Systemic inflammatory response syndrome (SIRS) is an early marker of sepsis and ongoing inflammation and has been reported in large proportion of acute-on-chronic liver failure (ACLF) patients. Whether sepsis is the cause or the result of liver failure is unclear and is vital to ...
Authia P Gray, Erin Chung, Rebecca Hsu, Daniel T Araki et al.
BACKGROUND: The global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic a...
Saskia M. Burm, Ella A. Zuiderwijk‐Sick, Anke E. J. 't Jong, Céline van der Putten et al.
Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas inflammasome-mediated activation is heavily studied in hematopoietic macrophages and dendritic cells, much less is known about...
Russell A. Johnson, Taher Uddin, Amena Aktar, M. Mohasin et al.
Immunity against Vibrio cholerae O1 is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) part of lipopolysaccharide (LPS). Despite this, human immune responses to V. cholerae OSP have not previously been characterized. We assessed immune responses against V. chol...
Mark L. Kuijf, Janneke N. Samsom, Wouter van Rijs, Marieke Bax et al.
In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. jejuni LOS modulate dendritic cell (DC) activation and subsequent B ...
Samaneh Maysami, Raymond Wong, Jesús M. Pradillo, Ádám Dénes et al.
Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in part, due to the low quality of preclinical studie...
W D B Clements, P Erwin, Mark McCaigue, I Halliday et al.
BACKGROUND: Endotoxaemia is implicated in the pathophysiology of obstructive jaundice. The EndoCab enzyme linked immunosorbent assay (ELISA) is a novel assay which measures endogenous antibody (IgG) to the inner core region of circulating endotoxins (ACGA). AIMS: To investigate the significance of e...
Judith L. Nerad, Jeffrey K. Griffiths, W M Jos, van der Meer et al.
The ability of an individual to mount defense responses to infection depend in part on the capacity to produce cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF). The specialized equipment, labor intensity, and sterile practice required for the standard in vitro evaluation of cyt...
Kenneth R. Feingold, Carl Grünfeld
Products of gram negative bacteria (LPS), gram positive bacteria (lipoteichoic acid), fungi (zymosan), and viruses (RNA) are recognized by toll receptors on macrophages and other cells and thereby induce marked changes in lipid and lipoprotein metabolism (1Khovidhunkit W. Kim M S Memon R A Shigenaga...
Robert E. Black, Douglas Huber, George T. Curlin
Immunization of non-pregnant women in rural Bangladesh with two doses of aluminium-adsorbed tetanus-diphtheria toxoids reduced neonatal mortality by one-third during a period of 9-32 months after vaccination. The reduction in mortality rate was attributable almost entirely to a 75% lower mortality r...
Crystal N. Ellis, Regina C. LaRocque, Taher Uddin, Bryan Krastins et al.
Vibrio cholerae O1 is a major cause of acute watery diarrhea in over 50 countries. Evidence suggests that V. cholerae O1 may activate inflammatory pathways, and a recent study of a Bangladeshi population showed that variants in innate immune genes play a role in mediating susceptibility to cholera. ...
Ralph Zirngibl, Yotis A. Senis, Peter A. Greer
The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase implicated in growth factor and cytokine receptor signaling and thought to be essential for the survival and terminal differentiation of myeloid progenitors. Fps/Fes-null mice were healthy and fertile, displayed slightly reduce...
Julie A. Preston, Martin A. Bewley, Helen M. Marriott, A. McGarry Houghton et al.
Abstract Rationale Antimicrobial resistance challenges therapy of pneumonia. Enhancing macrophage microbicidal responses would combat this problem but is limited by our understanding of how alveolar macrophages (AMs) kill bacteria. Objectives To define the role and mechanism of AM apoptosis–associat...