Robert W Aldridge, Dan Lewer, Srinivasa Vittal Katikireddi, Rohini Mathur et al.
<ns4:p> <ns4:bold>Background</ns4:bold> : International and UK data suggest that Black, Asian and Minority Ethnic (BAME) groups are at increased risk of infection and death from COVID-19. We aimed to explore the risk of death in minority ethnic groups in England using data reported by NHS England. <...
Masayuki Teramoto, Kanyin Liane Ong, Damian Santomauro, A Bhoomadevi et al.
BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and risk-attribut...
Kaixuan Zeng, Bangshun He, Burton B. Yang, Tao Xu et al.
BACKGROUND: Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer. METHODS: CircANKS1B (a circRNA originated from exons 5 to 8 of the ANKS1B gene, hsa_circ_0007294) was identified by RNA-sequencing and...
Mark Petticrew, Ruth Bell, Duncan Hunter
Abstract Objective: To summarise the evidence on the effect of psychological coping styles (including fighting spirit, helplessness/hopelessness, denial, and avoidance) on survival and recurrence in patients with cancer. Design: Systematic review of published and unpublished prospective observationa...
Habtamu Mellie Bizuayehu, Kedir Y. Ahmed, Getiye Dejenu Kibret, Abel Fekadu Dadi et al.
Importance: Cancer prevention and care efforts have been challenged by the COVID-19 pandemic and armed conflicts, resulting in a decline in the global Human Development Index (HDI), particularly in low- and middle-income countries. These challenges and subsequent shifts in health care priorities und...
Mohammad Nasir Uddin, Sayeda Samina Ahmed, S. M. Rahatul Alam
Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. For design and development of various bio...
Silke Reinartz, Tim Schumann, Florian Finkernagel, Annika Wortmann et al.
Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these tumor-associated macrophages (TAMs) are skewed to alternative polarization (M2) and thereby play an essential role in therapy resistance and metasta...
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan et al.
Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to both radiation and chemotherapy. This resistance is largely due to the unique biology of GBM cells, which can evade the effects of conventional treatments through mechanisms ...
Matthew R. Sydes, Melissa Spears, Malcolm D. Mason, Noel W. Clarke et al.
Background: Adding abiraterone acetate with prednisolone (AAP) or docetaxel with prednisolone (DocP) to standard-of-care (SOC) each improved survival in systemic therapy for advanced or metastatic prostate cancer: evaluation of drug efficacy: a multi-arm multi-stage platform randomised controlled pr...
Md. Rezaul Islam, Shopnil Akash, Md. Mominur Rahman, Feana Tasmim Nowrin et al.
Colon cancer affects both men and women and is the world's second most significant cause of cancer-related mortality. Colon cancer death rates have risen worldwide due to the current food habit and lifestyle, which include a lot of meat, alcohol, and not enough physical exercise. As a result, novel,...
Sarmistha Mitra, Raju Dash
Among all types of cancer, breast cancer is one of the most challenging diseases, which is responsible for a large number of cancer related deaths. Hormonal therapy, surgery, chemotherapy, and radiotherapy have been used as treatment of breast cancer, for a very long time. Due to severe side effects...
Annette Pflugfelder, Corinna Kochs, Andreas Blum, Marcus Capellaro et al.
This first German evidence-based guideline for cutaneous melanoma was developed under the auspices of the German Dermatological Society (DDG) and the Dermatologic Cooperative Oncology Group (DeCOG) and funded by the German Guideline Program in Oncology. The recommendations are based on a systematic ...
Neel Sengupta, Christopher Yau, Anuratha Sakthianandeswaren, Dmitri Mouradov et al.
BACKGROUND: Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features. METHODS: We characterized the clinicopathological features of BAN CRCs and interrogated their ge...
Christine D. Palmer, Amy Rappaport, Matthew J. Davis, Meghan G. Hart et al.
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, h...
Sylvia Varland, Camilla Osberg, Thomas Arnesen
The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. Methionine aminopeptidases excise the initiator methionine leaving the nascent p...