Aldenora Oliveira do Nascimento Holanda, Ana Raquel Soares de Oliveira, Kyria Jayanne Clímaco Cruz, Juliana Soares Severo et al.
Zinc is the catalytic component of proteins that regulate responses to DNA damage, intracellular signaling enzymes, and matrix metalloproteinases, which are important proteins in carcinogenesis. The objective of this review is to bring current information on the participation of zinc and matrix meta...
Md. Towhedul Islam, Nak Han Jang, Hyuck Jin Lee
Cancers are currently the major cause of mortality in the world. According to previous studies, matrix metalloproteinases (MMPs) have an impact on tumor cell proliferation, which could lead to the onset and progression of cancers. Therefore, regulating the expression and activity of MMPs, especially...
Yanping Wu, Chao Wang, Jiaqi Guo, Abdlay Carvalho et al.
was synthesized by sequential modification of PEGylated TTQ, followed by c(RGD) condensation. Signal strength was continuously monitored for 24 h following TTQ-PEG-c(RGD) or non-specific fluorescent dye injection. The contralateral external jugular vein, sham surgery and a competitive inhibition exp...
Shalini Mathpal, Priyanka Sharma, Tushar Joshi, Veena Pande et al.
The overexpression of matrix metalloproteinase-9 (MMP-9) is associated with tumor development and angiogenesis, and hence, it has been considered an attractive drug target for anticancer therapy. To assist in drug design endeavors for MMP-9 targets, an in silico study was presented to investigate wh...
Raphael Aminu, Mohammed Auwal Ibrahim, Md. Atiar Rahman, Raju Dash et al.
BACKGROUND The search for novel antitrypanosomal agents had previously led to the isolation of ellagic acid as a bioactive antitrypanosomal compound using in vitro studies. However, it is not known whether this compound will elicit antitrypanosomal activity in in vivo condition which is usually the ...
Romaisa Arshad, Waleed A. Ismail, Batool Zara, Rabia Naseer et al.
Chronic periodontitis and diabetes mellitus share a two-way relationship, the common factor being the inflammatory-mediated pathway, and various cytokines are released during this inflammatory cascade, one of which being matrix metalloproteinase-9. The aim of this study was to identify whether the l...
Md. Maruf Hasan, Abu Rashed Md. Shawon, Abdullah Aeyas, M. Ashraf Uddin
Matrix metalloproteinases-1 is recognized as a potential target of tumors and cancer for their role in breaking down collagen and extracellular matrix proteins. Our study screened 51 peptides against MMP-1 to find potent inhibitors for preventing breast cancer metastasis. Since cyclic peptides have ...
Zheng Qiu, Jialiang Hu, Hanmei Xu, Wenjing Wang et al.
Previous applications of matrix metalloproteinase (MMP) inhibitors in cancer treatment have resulted in disappointing outcomes. Therefore, it is necessary to develop more active or better targeted MMP inhibitors. In this study, Inhibitor2, a heptapeptide MMP inhibitor, was connected to the N-terminu...
Sharmin Akter, Shihab Ahmad, Mohiuddin Ahmed Bhuiyan, Irin Dewan et al.
Background: Diabetic wounds are a significant clinical challenge due to impaired healing processes often exacerbated by elevated matrix metalloproteinases (MMPs). Cinnamomum zeylanicum , known for its anti-inflammatory and antioxidant properties, has shown potential in promoting wound healing. This ...
Ayana Murakami, Nobuhiro Mano, Mahfujur Rahman, Hitomi Hirose
Efthimios Dardiotis, G. Hadjigeorgiou, Maria Dardioti, Nikolaos Scarmeas et al.
BACKGROUND/AIMS: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective stud...
Behnaz Parhami-Seren, Tracy Keel, Guy L. Reed
In order to determine the nature of the antigenic and functional determinants of streptokinase (SK), we produced monoclonal antibodies (MAbs) by immunizing A/J mice with native SK protein. By virtue of their differential binding to a large panel of recombinant SK truncated proteins, and their effect...
Yves Taeymans, P Materne
Patients admitted within 4 hours of the onset of chest pain suggestive of acute myocardial infarction were randomised to either intravenous anisoylated plasminogen streptokinase activator complex (APSAC) 30U or heparin 5000U (44 vs 38 patients). Angiograms were obtained between days 10 and 15 after ...
Yu Cai, Shou Leng, Yuanyuan Ma, Tingting Xu et al.
By utilizing NIRF imaging, diabetic stroke mice were visualized with a trend of higher levels of MMP-9 than wild-type mice. CD28 SA down-regulated the expression of MMP-9 and represents a potential treatment to diabetic stroke.
Xiaolin Liu, Tengfei Zheng, Yu Zhang, Yachao Zhao et al.
Our findings demonstrate that, endothelial DKK1, induced by pathological low shear stress, acts as an intercellular mediator, promoted the foam cell formation of SMCs. These results suggest that targeted intervention with endothelial DKK1 may confer beneficial effects on atherosclerosis.