Giacomo Bellani, John G. Laffey, Tài Pham, Eddy Fan et al.
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation manag...
Walter Vincken, J.A. van Noord, A.P.M. Greefhorst, Th.A. Bantje et al.
Tiotropium, a novel once-daily inhaled anticholinergic, has been shown to improve lung function over a 24-h period. In order to extend these findings, health-outcomes were evaluated over 1 yr in chronic obstructive pulmonary disease (COPD) patients. Spirometric results, peak expiratory flow rate (PE...
Mario Kinsella, Néstor L. Müller, Raja T. Abboud, Nancy Morrison et al.
We used a CT program "density mask" outlining areas with attenuation values less than -910 HU, to indicate areas of emphysema on a chest CT and to provide an overall percentage of lung involvement by emphysema. The "density mask" quantitation of emphysema was previously shown to correlate well with ...
Guillaume Émériaud, Yolanda M. López‐Fernández, Narayan P. Iyer, Melania M. Bembea et al.
OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. D...
Mohammod Jobayer Chisti, Mohammed Abdus Salam, Jonathan H. Smith, Tahmeed Ahmed et al.
Background In developing countries, mortality in children with very severe pneumonia is high, even with the provision of appropriate antibiotics, standard oxygen therapy, and other supportive care. We assessed whether oxygen therapy delivered by bubble continuous positive airway pressure (CPAP) impr...
John Muscedere, Tasnim Sinuff, Daren K. Heyland, Peter Dodek et al.
Background Ventilator-associated conditions (VACs) and infection-related ventilator-associated complications (iVACs) are the Centers for Disease Control and Prevention's new surveillance paradigms for patients who are mechanically ventilated. Little is known regarding the clinical impact and prevent...
Ahsab Rahman, Tahani Tabassum, Yusha Araf, Abdullah Al Nahid et al.
The novel coronavirus disease 2019 (COVID-19) has become a severe health issue, especially to the patients who develop silent hypoxia condition after SARS-CoV-2 infection. Due to the lack of dyspnoea and extremely low oxygen saturation level, these patients are at exceptionally higher risk. Although...
Ozan Akça, Anthony G. Doufas, Nobutada Morioka, Steve Iscoe et al.
BACKGROUND: Wound infections are common, serious, surgical complications. Oxidative killing by neutrophils is the primary defense against surgical pathogens and increasing intraoperative tissue oxygen tension markedly reduces the risk of such infections. Since hypercapnia improves cardiac output and...
Jordan A. Guenette, Roberto C. Chin, Sicheng Cheng, Paolo B. Dominelli et al.
The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative...
David Comer, Joseph C. Kidney, Madeleine Ennis, J.S. Elborn
We hypothesised that primary bronchial epithelial cells (PBECs) from subjects with chronic obstructive pulmonary disease (COPD) respond differently to Pseudomonas aeruginosa lipopolysaccharide (LPS) after cigarette smoke extract (CSE) exposure than PBECs obtained from smokers without airflow obstruc...
Raphaël Cinotti, Julio Mijangos, Paolo Pelosi, Matthias Hænggi et al.
Purpose Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical ventilation. Methods ENIO (NCT03400904) is an international, prospective observation...
Silvia Schnyder‐Candrian, Valérie Quesniaux, Franco Di Padova, Isabelle Maillet et al.
Abstract The administration of endotoxins from Gram-negative bacteria induces manifestations reminding of acute respiratory distress syndrome. p38 MAPKs have been implicated in this pathology. In this study, we show that the specific p38 α,β MAPK inhibitor, compound 37, prevents LPS-induced bronchoc...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan
An incomplete understanding of the molecular mechanisms behind impairment of lung pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed the gene expression pattern of cells obtained from biopsies of COVID-19-affected patient and compared to the effects observed in ...
Philip H. Quanjer, Gregg L Ruppel, Arnulf Langhammer, Abhishek Krishna et al.
Background Recommendations on interpreting tests of bronchodilator responsiveness (BDR) are conflicting. We investigated the dependence of BDR criteria on sex, age, height, ethnicity, and severity of respiratory impairment. Methods BDR test data were available from clinical patients in the Netherlan...
Jian Luo, Trevor Duke, Mohammod Jobayer Chisti, Elizabeth Kepreotes et al.
OBJECTIVES To evaluate the efficacy of high-flow nasal cannula (HFNC) oxygen therapy in providing respiratory support of children with acute lower respiratory infection (ALRI), hypoxemia, and respiratory distress. STUDY DESIGN We performed a meta-analysis of randomized controlled trials that compare...