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16+ results
Field: Stereochemistry

Phytol: A review of biomedical activities

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Muhammad Torequl Islam, Eunüs S. Ali, Shaikh Jamal Uddin, Subrata Shaw et al.

Journal: Food and Chemical ToxicologyYear: 2018
Citations: 459

Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applicat...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2

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Rajib Islam, Md. Rimon Parves, Archi Sundar Paul, Nizam Uddin et al.

Journal: Journal of Biomolecular Structure and DynamicsYear: 2020Citations: 347

value of 0.842 for the training set and 0.753 for the test set. Our proposed MLR model can predict the favorable binding energy compared with the binding energy detected from molecular docking. ADMET analysis demonstrates that these candidates appear to be safer inhibitors. Our comprehensive computa...

Physical SciencesComputer ScienceComputational Theory and MathematicsOpen Access
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REVIEW: Biomedical applications of Schiff base metal complexes

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Mohammad Nasir Uddin, Sayeda Samina Ahmed, S. M. Rahatul Alam

Journal: Journal of Coordination ChemistryYear: 2020Citations: 284

Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. For design and development of various bio...

Health SciencesMedicineOncology
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A new structural alternative in benzo[b]furans for antimicrobial activity

Verified

Md. Wahab Khan, Mohammad Jahangir Alam, Mohammad Mamun Ur Rashid, Rasheduzzaman Chowdhury

Journal: Bioorganic & Medicinal ChemistryYear: 2005Citations: 283

Two series of 2-substituted and three new diacetyl benzofurans were synthesized through palladium-catalyzed reactions and their in vitro antimicrobial spectra were assessed. The compounds demonstrated mild to significant growth inhibition against antibiotic-susceptible standard and clinically isolat...

Physical SciencesChemistryOrganic Chemistry
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Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.

Verified

Sriram Krishnaswamy, W R Church, Michael E. Nesheim, Kenneth G. Mann

Journal: Journal of Biological ChemistryYear: 1987Citations: 278

The kinetics of the activation of human prothrombin catalyzed by human prothrombinase was studied using the fluorescent alpha-thrombin inhibitor dansylarginine-N-(3-ethyl-1,5-pentanediyl)amide (DAPA). Prothrombinase proteolytically activates prothrombin to alpha-thrombin by cleavages at Arg273-Thr27...

Health SciencesMedicineHematologyOpen Access
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Tautomeric mixture coordination enables efficient lead-free perovskite LEDs

Verified

Dongyuan Han, Jie Wang, Lorenzo Agosta, Ziang Zang et al.

Journal: NatureYear: 2023Citations: 263

Lead-free perovskite light-emitting diodes (LEDs) prepared using tautomeric mixture coordination provide improved ordering in the crystal structure, reduced recombination and enhanced exciton binding energy compared with lead-containing perovskite-based LEDs. Lead halide perovskite light-emitting di...

Physical SciencesEngineeringElectrical and Electronic EngineeringOpen Access
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Anticancer agents from medicinal plants

Verified

Mohammad Shoeb

Journal: Bangladesh Journal of PharmacologyYear: 2008Citations: 259

Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Several anticancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from ...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Structure–activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues

Verified

Mahmud Tareq Hassan Khan, M. Iqbal Choudhary, Khalid Mohammed Khan, Mubeen Rani et al.

Journal: Bioorganic & Medicinal ChemistryYear: 2005Citations: 209

Here the tyrosinase inhibition studies of library of 2,5-disubstituted-1,3,4-oxadiazoles have been reported and their structure-activity relationship (SAR) also have been discussed. The library of the oxadiazoles was synthesized under the microwave irradiation and was structures of these were charac...

Life SciencesBiochemistry, Genetics and Molecular BiologyCell Biology
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Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity

Verified

Mohammad Sayed Alam, Jung‐Hyun Choi, Dong‐Ung Lee

Journal: Bioorganic & Medicinal ChemistryYear: 2012Citations: 189

4-Aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and its analogues have been found to be compounds of interest for their anti-inflammatory, analgesic, antiviral, antipyretic, antirheumatic and antimicrobial activities. In the present study, Schiff base analogues of 4-aminoantipyrine w...

Physical SciencesChemistryOrganic Chemistry
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The preparation, characterization, crystal structure and biological activities of some copper(II) complexes of the 2-benzoylpyridine Schiff bases of S-methyl- and S-benzyldithiocarbazate

Verified

Mir Ezharul Hossain, Mohammad Nurul Alam, Jaripa Begum, Mohammad Akbar Ali et al.

Journal: Inorganica Chimica ActaYear: 1996Citations: 180
Health SciencesMedicineOncology
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Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh

Verified

Reingard Raml, Alice Rumpler, Walter Goessler, Marie Vahter et al.

Journal: Toxicology and Applied PharmacologyYear: 2006Citations: 176

Over the last 6 years, much work on arsenic species in urine samples has been directed toward the determination of the reduced dimethylated arsenic species, DMA(III), because of its high toxicity and perceived key role in the metabolism of inorganic arsenic. Recent work, however, has suggested that ...

Physical SciencesEnvironmental ScienceEnvironmental Chemistry
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ATP-sulfurylase, sulfur-compounds, and plant stress tolerance

Verified

Naser A. Anjum, Ritu Gill, Manjeri Kaushik, Mirza Hasanuzzaman et al.

Journal: Frontiers in Plant ScienceYear: 2015Citations: 170

Sulfur (S) stands fourth in the list of major plant nutrients after N, P, and K. Sulfate (SO4 (2-)), a form of soil-S taken up by plant roots is metabolically inert. As the first committed step of S-assimilation, ATP-sulfurylase (ATP-S) catalyzes SO4 (2-)-activation and yields activated high-energy ...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Verified

Faisal Omar, Abu Montakim Tareq, Ali Alqahtani, Kuldeep Dhama et al.

Journal: MoleculesYear: 2021Citations: 169

Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review's fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provi...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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Protein conformational effect in hydrophobic interaction chromatography

Verified

Shiaw‐Lin Wu, Álvaro A. Figueroa, Barry L. Karger

Journal: Journal of Chromatography AYear: 1986Citations: 143

We have studied the conformational behavior of alpha-lactalbumin (alpha-LACT) in hydrophobic interaction chromatography (HIC). Retention characterization in terms of Z (slope of plot of ln k' vs. ln phi B, where k' is the capacity factor and phi B is the volume fraction of mobile phase B) has been e...

Physical SciencesChemistrySpectroscopy
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In vivo anticancer activity of vanillin semicarbazone

Verified

Shaikh M Mohsin Ali, M. A. K. Azad, Mele Jesmin, Shamim Ahsan et al.

Journal: Asian Pacific Journal of Tropical BiomedicineYear: 2012Citations: 136

OBJECTIVE: To evaluate the anticancer activity of vanillin semicarbazone (VSC) against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. METHODS: The compound VSC at three doses (5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observ...

Life SciencesBiochemistry, Genetics and Molecular BiologyBiotechnologyOpen Access
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