Eileen E. Parkes, Steven M. Walker, Laura E. Taggart, Nuala McCabe et al.
Background: Previously we identified a DNA damage response-deficient (DDRD) molecular subtype within breast cancer. A 44-gene assay identifying this subtype was validated as predicting benefit from DNA-damaging chemotherapy. This subtype was defined by interferon signaling. In this study, we address...
Md. Abdul Alim Al‐Bari
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for t...
Joanne Elliott, Oonagh T. Lynch, Yvonne Suessmuth, Ping Qian et al.
Respiratory syncytial virus (RSV) infection causes bronchiolitis and pneumonia in infants. RSV has a linear single-stranded RNA genome encoding 11 proteins, 2 of which are nonstructural (NS1 and NS2). RSV specifically downregulates STAT2 protein expression, thus enabling the virus to evade the host ...
Zhifa Wen, Hongxiang Liu, Rong Gao, Meng Zhou et al.
<h3>Background</h3> Tumor-associated macrophages (TAMs) facilitate tumor progression via establishment of an immunosuppressive tumor microenvironment (TME). However, it is poorly understood how tumor cells could functionally modulate TAMs. Our previous work indicated that tumor cell-released autopha...
Russell A. Mittermeier, William R. Konstant, Martin E. Nicoll, Olivier Landgrand
Habitats and their living natural resources are under increasing pressures everywhere from humankind. Species, the basic biotic units, are consequently increasingly threatened with extinction. To protect and conserve biodiversity from species level to ecosystems requires management based on understa...
Abdullah Al Mamun, Yanqing Wu, Chang Jia, Fahad Munir et al.
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory in...
Qiujing Yu, Christopher J. Carbone, Yuliya V. Katlinskaya, Hui Zheng et al.
Type I interferons (IFN) including IFNα and IFNβ are critical for the cellular defense against viruses. Here we report that increased levels of IFNβ were found in testes from mice deficient in MOV10L1, a germ cell-specific RNA helicase that plays a key role in limiting the propagation of retrotransp...
Tania Islam, Md Rezanur Rahman, Büşra Aydın, Hande Beklen et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease, more commonly COVID-19 has emerged as a world health pandemic. There are couples of treatment methods for COVID-19, however, well-established drugs and vaccines are urgently needed to treat the COVID-19. The new drug discovery is ...
Liang Wu, Xiaolong Zhang, Zhikun Zhao, Ling Wang et al.
BACKGROUND: Viral infection causes multiple forms of human cancer, and HPV infection is the primary factor in cervical carcinomas. Recent single-cell RNA-seq studies highlight the tumor heterogeneity present in most cancers, but virally induced tumors have not been studied. HeLa is a well characteri...
David Mitzner, Sabine Eva Dudek, Nicole Studtrucker, Darisuren Anhlan et al.
The 11(th) influenza A virus (IAV) protein PB1-F2 is encoded by an alternative reading frame of the PB1 polymerase gene and found in the nucleus, cytosol and at the mitochondria of infected cells, the latter is consistent with experimental evidence for its pro-apoptotic function. Here, the function ...
Wei Song, Chuqian Zheng, Min Liu, Ying Xu et al.
Hepatocellular carcinoma (HCC) is among the most common malignancies and has an unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein is closely associated with hepatocarcinogenesis. Sorafenib is a unique targeted oral kinase inhibitor for advanced HCC. Long noncoding RNAs (lncRNAs) m...
Abul Bashar Mir Md. Khademul Islam, Md. Abdullah‐Al‐Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain et al.
Abstract Background Although it is becoming evident that individual’s immune system has a decisive influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this study, we aimed to profile the host transcriptome of COVID-19 patients from nasopharyngeal samples along with virus...
Hyun‐Cheol Lee, Eun‐Seo Lee, Md Bashir Uddin, Tae‐Hwan Kim et al.
ARSs are essential enzymes in translation that link specific amino acids to their cognate tRNAs. In higher eukaryotes, some ARSs possess additional, noncanonical functions in the regulation of cell metabolism. Here, we report a novel noncanonical function of WRS in antiviral defense. WRS is rapidly ...
Majd Ariss, Abul Bashar Mir Md. Khademul Islam, Meg Critcher, María Paula Zappia et al.
The function of Retinoblastoma tumor suppressor (pRB) is greatly influenced by the cellular context, therefore the consequences of pRB inactivation are cell-type-specific. Here we employ single cell RNA-sequencing (scRNA-seq) to profile the impact of an Rbf mutation during Drosophila eye development...
Abdullah Al Mamun, Anjuman Ara Mimi, Md. Abdul Aziz, Muhammad Zaeem et al.
Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis has notably been gained extensive attention from clinicians and researchers. However, current studies report that downr...