Karine Brudey, Jeffrey Driscoll, Leen Rigouts, Wolfgang M. Prodinger et al.
BACKGROUND: The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic dive...
Nicola Ragge, Alison G. M. Brown, Charlotte M. Poloschek, Birgit Lorenz et al.
Major malformations of the human eye, including microphthalmia and anophthalmia, are examples of phenotypes that recur in families yet often show no clear Mendelian inheritance pattern. Defining loci by mapping is therefore rarely feasible. Using a candidate-gene approach, we have identified heteroz...
Intza Garin, Emma L. Edghill, İldem Akerman, Oscar Rubio‐Cabezas et al.
Heterozygous coding mutations in the INS gene that encodes preproinsulin were recently shown to be an important cause of permanent neonatal diabetes. These dominantly acting mutations prevent normal folding of proinsulin, which leads to beta-cell death through endoplasmic reticulum stress and apopto...
Supriya Gupta, Ashmita Patro, Yamini Mittal, Saurabh Dwivedi et al.
Microbial fuel cell (MFC) is an interesting technology capable of converting the chemical energy stored in organics to electricity. It has raised high hopes among researchers and end users as the world continues to face climate change, water, energy, and land crisis. This review aims to discuss the ...
Laurent Charlet, Guillaume Morin, Jérôme Rose, Yuheng Wang et al.
Massive deleterious impacts to human health are resulting from the use of arsenic-bearing groundwaters in South-East Asia deltas and elsewhere in the world for drinking, cooking and/or irrigation. In Bangladesh alone, a fifth of all deaths are linked to arsenicosis. In the natural and engineered sub...
Silvia E. Arranz, Jean‐Christophe Avarre, Chellam Balasundaram, Carmen Bouza et al.
Abstract This article documents the addition of 268 microsatellite marker loci to the M olecular E cology R esources D atabase. Loci were developed for the following species: A lburnoides bipunctatus, C hamaerops humilis, C hlidonias hybrida, C yperus papyrus, F usarium graminearum, L oxigilla barba...
Friday Ojie Ehiguese, Md Rushna Alam, Marina G. Pintado‐Herrera, Cristiano V.M. Araújo et al.
Polycyclic musk compounds have been identified in environmental matrices (water, sediment and air) and in biological tissues in the last decade, yet only minimal attention has been paid to their chronic toxicity in the marine environment. In the present research, the clams Ruditapes philippinarum we...
Theresa S P Rothenbücher, Hakan Gürbüz, Marta P. Pereira, Arto Heiskanen et al.
Brain organoids are considered to be a highly promising in vitro model for the study of the human brain and, despite their various shortcomings, have already been used widely in neurobiological studies. Especially for drug screening applications, a highly reproducible protocol with simple tissue cul...
Olga Vera, Carlos Rodríguez‐Antolín, Ana Salgado-Figueroa, Patrycja Michalska et al.
Adjuvant chemotherapy for solid tumors based on platinum‐derived compounds such as cisplatin is the treatment of choice in most cases. Cisplatin triggers signaling pathways that lead to cell death, but it also induces changes in tumor cells that modify the therapeutic response, thereby leading to ci...
Roser Vento‐Tormo, Javier Rodríguez‐Ubreva, Lorena Di Lisio, Abul Bashar Mir Md. Khademul Islam et al.
MicroRNAs (miRNAs) have negative effects on gene expression and are major players in cell function in normal and pathological conditions. Epstein-Barr virus (EBV) infection of resting B lymphocytes results in their growth transformation and associates with different B cell lymphomas. EBV-mediated B ...
Paolo Ronza, Asunción Cao, Diego Robledo, Antonio Gómez‐Tato et al.
European flat oyster (Ostrea edulis) production has suffered a severe decline due to bonamiosis. The responsible parasite enters in oyster haemocytes, causing an acute inflammatory response frequently leading to death. We used an immune-enriched oligo-microarray to understand the haemocyte response ...
Abul Farah Md. Hasanuzzaman, Diego Robledo, Antonio Gómez‐Tato, José Antonio Álvarez‐Dios et al.
Ruditapes philippinarum, one of the major contributors to the global mollusc production, is susceptible to perkinsosis, a disease caused by the protozoan Perkinsus olseni (Alveolata, Perkinsidae). Understanding the molecular response of Manila clam defence cells (haemocytes) to this parasite is esse...
M. Cappetta, R. P. Saglia, Jayne Birkby, J. Koppenhoefer et al.
We report the discovery of WTS-1b, the first extrasolar planet found by the WFCAM Transit Survey, which began observations at the 3.8-m United Kingdom Infrared Telescope (UKIRT) in 2007 August. Light curves comprising almost 1200 epochs with a photometric precision of better than 1 per cent to J ∼ 1...
Miguel Alcoceba, Peter Stewart, María García‐Álvarez, Luis G. Díaz et al.
Circulating tumour DNA (ctDNA) allows genotyping and minimal residual disease (MRD) detection in lymphomas. Using a next-generation sequencing (NGS) approach (EuroClonality-NDC), we evaluated the clinical and prognostic value of ctDNA in a series of R-CHOP-treated diffuse large B-cell lymphoma (DLBC...
Cristina Rodríguez, Irene Sánchez‐Morán, Sara Álvarez, Pilar Tirado et al.
The Fizzy-related protein 1 (Fzr1) gene encodes Cdh1 protein, a coactivator of the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). Previously, we found that genetic ablation of Fzr1 promotes the death of neural progenitor cells leading to neurogenesis impairment and microcephaly in...
Kerstin Daniela Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra et al.
BACKGROUND: Improvements in the early diagnosis of dengue are urgently needed, especially in resource-limited settings where the distinction between dengue and other febrile illnesses is crucial for patient management. METHODS: In this prospective, observational study (IDAMS), we included patients a...
Abul Farah Md. Hasanuzzaman, Diego Robledo, Antonio Gómez‐Tato, José Antonio Álvarez‐Dios et al.
The protistan parasite Perkinsus olseni is a deadly causative agent of perkinsosis, a molluscan disease affecting Manila clam (Ruditapes philippinarum), having a significant impact on world mollusc production. Deciphering the underlying molecular mechanisms in R. philippinarum-P. olseni interaction ...
Didier Bazile, Emilio A. Martı́nez, Francisco Fuentes
Chile, isolated by a hyper-arid desert in the north, the Andes Range to the east and the Pacific and Antarctic waters (west and south), has a highly endemic flora. This hotspot of biodiversity is in danger not only due to increasing desertification, but also because human activities can diminish agr...
Md Rushna Alam, Friday Ojie Ehiguese, Dyana Vitale, M.L. Martı́n-Dı́az
The elevated concentration of hydrogen peroxide (H2O2) due to natural and anthropogenic causes is a significant bane to marine and coastal organisms, as it has a prolonged half-life and can inject across lipid bilayers and interfere with aquatic redox processes. The present assessment aimed to deter...
Jiang Xiao, Zengchao Guo, Gang Lv, Zhihong Yan et al.
Excessive use of antibiotics and the formation of bacterial biofilms can lead to persistent infections caused by drug-resistant bacteria, rendering ineffective immune responses and even life-threatening. There is an urgent need to explore synergistic antibacterial therapies across all stages of infe...