Qian Li, Liwen Yu, Amy Gao, Ruiqing Ren et al.
Background: Atherosclerosis is a chronic inflammatory disease, in which macrophages determine the progression of atherosclerotic plaques. However, no studies have investigated how METTL3 (methyltransferase like 3) in macrophages affects atherosclerotic plaque formation in vivo. Additionally, whether...
Jie Zhang, Lei Cao, Xiaohong Wang, Qian Li et al.
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive renal disease (HRD). However, the signaling mechanisms underlying their induction are poorly understood, and the role of tripartite motif-containing protein 31 (TRIM31), an E3 ubiquitin ligase, in HRD rem...
Liwen Yu, Jie Zhang, Amy Gao, Meng Zhang et al.
Abstract The developmental origin, anatomical location, and other factors contribute to aortic heterogeneity in a physiological state. On this basis, vascular diseases occur at different ratios based on position specificity, even with the same risk factor. However, the continuous intersegmental aort...
Ben Y. Zhao, Cong Xia, Tianyi Xia, Yue Qiu et al.
BACKGROUND: Undetectable occult liver metastases block the long-term survival of pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop a radiomics-based model to predict occult liver metastases and assess its prognostic capacity for survival. MATERIALS AND METHODS: Patients who underw...
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren et al.
Innate immunity is the first line to defend against pathogenic microorganisms, and Toll-like receptor (TLR)-mediated inflammatory responses are an essential component of innate immunity. However, the regulatory mechanisms of TLRs in innate immunity remain unperfected. We found that the expression of...
Zunzhe Wang, Huating Wang, Zhang Ya, Fangpu Yu et al.
This study aimed to characterize the cells and gene expression landscape in atrial septal defect (ASD). We performed single-cell RNA sequencing of cells derived from cardiac tissue of an ASD patient. Unsupervised clustering analysis was performed to identify different cell populations, followed by t...
Dianliang Zhang, Yun Ding, Qing Mi, Wenzhen Qian et al.
Zhongfan Luo, Jingjing Chen, Peishi Dong, Tonghuan Zhang et al.
Jie Zhang, Liwen Yu, Wei� Yang, Lei Cao et al.
BACKGROUND: Atherosclerosis is a chronic inflammatory disease marked by lipid accumulation and immune cell infiltration in arterial walls. Macrophages contribute by internalizing oxidized low-density lipoprotein, forming foam cells, and driving inflammation. The ubiquitin–proteasome system regulates...
Sheng-Yan Tang, Xiaohu Liu, Wenwen Fei, Liwen Fan et al.
Owing to its high energy utilization and penetrability, near-infrared II (NIR-II) photocatalysis has emerged as a promising catalytic mode. A central challenge in this research area is solving the contradiction between near-infrared absorption and efficient energy transfer. Organic ligand-protected ...
Liwen Huan, Yahong Zhang, Wenwen Liu, Hongyu Lu et al.
LNPs could not ameliorate acute liver injury induced by pulegone. Interestingly, bicyclol could attenuate that liver injury in mice, which may be related to the inhibition of hepatocyte apoptosis.
Yuxuan Wang, Jisheng Zhang, Pan Liu, Chengcheng Xu et al.
Non-green channel vehicles affect the normal operation and management of highways. This study investigates the different characteristics between green and non-green channel vehicles. The binary Logistic regression model was developed to screen suitable variables and identify the non-green channel ve...
Liwen Zhang, Zhaoji Miao, Yusong Shen, Zechen Wei et al.
Magnetic Particle Imaging (MPI) is an innovative medical modality, providing nanomolar-scale in vivo sensitivity and radiation-free dynamic real-time detection for precision medicine. However, MPI faces a challenging problem in accurately visualizing nanoparticle distributions, where the reconstruct...
Liwen Yue, Jie Min, Cannan Wang, Dan Hu et al.
OBJECTIVE: Using Bootstrap method to estimate the ratio of residual pollutants in processed foods to their raw materials in several common foods, comparing the conversion coefficient defined in this article and exploring its significance for applying in the future. METHODS: Several common foods sort...