Shafi Mahmud, Mohammad Abu Raihan Uddin, Gobindo Kumar Paul, Mst. Sharmin Sultana Shimu et al.
The new coronavirus (SARS-CoV-2) halts the world economy and caused unbearable medical emergency due to high transmission rate and also no effective vaccine and drugs has been developed which brought the world pandemic situations. The main protease (Mpro) of SARS-CoV-2 may act as an effective target...
Shafi Mahmud, Mohammad Abu Raihan Uddin, Meemtaheena Zaman, Khaled Mahmud Sujon et al.
Newly emerged SARS-CoV-2 made recent pandemic situations across the globe is accountable for countless unwanted death and insufferable panic associated with co-morbidities among mass people. The scarcity of appropriate medical treatment and no effective vaccine or medicine against SARS-CoV-2 has tur...
Shafi Mahmud, Md. Ekhtiar Rahman, Zulkar Nain, Mu’tasim Billah et al.
Carbonic anhydrase IX (hCAIX) is a membrane-spanning metalloenzyme, encoded by CA9 gene, which can lead to various carcinomas if upregulated. Due to its overexpression in many cancer tissues, hCAIX has become a promising target for developing anticancer therapeutics. Furthermore, several classes of ...
Md. Arif Khan, Shafi Mahmud, A. S. M. Rubayet Ul Alam, Md. Ekhtiar Rahman et al.
Recent outbreak of novel coronavirus and its rapid pandemic escalation in all over the world has drawn the attention to urgent need for effective drug development. However, due to prolonged vaccine and drug development procedure against a newly emerged devastating SARS-CoV-2 virus pathogen, repurpos...
Alomgir Hossain, Md. Ekhtiar Rahman, Md Siddiqur Rahman, Khondokar Nasirujjaman et al.
Highly transmissive and rapidly evolving Coronavirus disease-2019 (COVID-19), a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), triggered a global pandemic, which is one of the most researched viruses in the academia. Effective drugs to treat people with COVID-1...
Shafi Mahmud, Gobindo Kumar Paul, Suvro Biswas, Taheruzzaman Kazi et al.
The phytochemicals of medicinal plants are regarded as a rich source of diverse chemical spaces that have been used as supplements and alternative medicines in the millennium. Even in this era of combinatorial chemical drugs, phytomedicines account for a large share of the statistics of newly approv...
Alomgir Hossain, Md. Ekhtiar Rahman, Md Omar Faruqe, Ahmed Saif et al.
Diabetes, characterized by elevated blood sugar levels, poses significant health and economic risks, correlating with complications like cardiovascular disease, kidney failure, and blindness. Dipeptidyl peptidase-4 (DPP-4), also referred to as T-cell activation antigen CD26 (EC 3.4.14.5.), plays a c...
Md. Eram Hosen, Sumaiya Jahan Supti, Shopnil Akash, Md. Ekhtiar Rahman et al.
An excessive amount of multidrug-resistant Staphylococcus aureus is commonly associated with actinic keratosis (AK) and squamous cell carcinoma (SCC) by secreted virulence products that induced the chronic inflammation leading to skin cancer which is regulated by staphylococcal accessory regulator (...
Shafi Mahmud, Abdo A. Elfiky, Al Amin, Sumon Chandro Mohanto et al.
The newly emerged human coronavirus, SARS-CoV-2, had begun to spread last year and sparked worldwide. In this study, molecular docking is utilized to test some previously approved drugs against the SARS-CoV-2 nonstructural protein 15 (Nsp15). We screened 23 drugs, from which three (saquinavir, valru...
M. Alom, Rejwana Parvin Bonna, Ariful Islam, Md. Wasim Alom et al.
Alzheimer's disease (AD) is a serious threat to the global health care system and is brought on by a series of factors that cause neuronal dysfunction and impairment in memory and cognitive decline. This study investigated the therapeutic potential of phytochemicals that belong to the ten regularly ...
Jannatul Ferdous, Md. Ekhtiar Rahman, Farzana Sayed Sraboni, Amit Kumar Dutta et al.
Paederia foetida is valued for its folk medicinal properties. This research aimed to assess the acute toxicity, hypoglycemic and anti-hemostasis properties of the methanolic extract of P. foetida leaves (PFLE). Acute toxicity of PFLE was performed on a mice model. Hypoglycemic and anti-hemostasis pr...
Alomgir Hossain, Faria Tasnin Joti, M. S. Hossain, Abdullah Al-Noman et al.
Background: Dengue virus (DENV) is the fatal pathogenic arthropod-borne virus (arboviruses) that belongs to the Flaviviridae family, which transmits to humans through mosquito bites from infected Aedes aegypti and Aedes albopictus mosquitoes or maternal-fetal transmission. Despite antigenic differen...
Md. Ekhtiar Rahman, M. S. Hossain, Nabil Ahmed, Faria Tasnin Joti et al.
Mst. Kusum Kaly, Md. Ekhtiar Rahman, Md. Sohel Rana, Uzzal Kumar Acharjee et al.
This study investigated the potential genotoxic and carcinogenic effects of N-nitrosodimethylamine (NDMA), a hazardous compound found in ranitidine formulations that are used to treat excessive stomach acid. The study first examined the effects of NDMA-contaminated ranitidine formulation on Allium c...
Fabiha Amin Chowdhury, Madhav Koirala, Md. Ekhtiar Hosen Tisham, M. Bishal Rahman et al.
ABSTRACT Superworm ( Zophobas morio F. ), the larva of the darkling beetle, is a widely used source of sustainable insect‐based protein for animal feed and organic waste biodegradation. Its growth and development are strongly influenced by diet composition, especially the inclusion of vegetables. In...
Alomgir Hossain, Md. Sanowar Hossan, Md. Shahanur Prodhan, Mariya Joy et al.
Fibroblast Growth Factor Receptor 2 (FGFR2) plays a critical role in cellular proliferation and differentiation, and its dysregulation is associated with multiple cancers. This study integrates molecular docking, deep learning, pharmacokinetic profiling, and molecular dynamics (MD) simulations to id...
Md. Ekhtiar Rahman, Alomgir Hossain, Md. Mahedi Hasan Sourov, Md. Muntasir Alam Muhib et al.
Amit Kumar Dutta, Md. Ekhtiar Rahman
Helicases are ubiquitous enzymes with specific functions that contribute to almost all nucleic acid metabolic processes. The RecQ helicase family is essential for integrity in all organisms through DNA replication, repair, and recombination. This study investigated five RecQ-like helicases in Arabid...
Jannatul Ferdous, Md. Ekhtiar Rahman, Farzana Sayed Sraboni, Amit Kumar Dutta et al.