Grace O’Malley, Oliver Treacy, Kevin Lynch, Serika D. Naicker et al.
Abstract Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as infiltrating hematopoietic immune cells. The importance of these cells ...
Matthew Alderdice, Susan D. Richman, Simon Gollins, Peter Stewart et al.
Colorectal cancer (CRC) biopsies underpin accurate diagnosis, but are also relevant for patient stratification in molecularly-guided clinical trials. The consensus molecular subtypes (CMSs) and colorectal cancer intrinsic subtypes (CRISs) transcriptional signatures have potential clinical utility fo...
Ryan Lusby, Philip D. Dunne, Vijay Tiwari
Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination and the underlying mechanisms governing invasion...
James W. Frey
Click to increase image sizeClick to decrease image size Notes1. This article presents research conducted in 1995–1997, funded in part by the History Department of the University of Wisconsin–Madison. The original version of this article first was presented at the Conference on Indian Military Histo...
Shania M. Corry, Amy M.B. McCorry, Tamsin R.M. Lannagan, Niamh Leonard et al.
Objective Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. Design To address the lack of efficacious therapeutic options for patients with stroma-rich CC, we stratified our human...
T.S. Hataley, Kim Richard Nossal
Abstract Enthusiasts of human security argue that what is needed in the post‐Cold‐War period is a foreign policy agenda that is more ‘people‐centred’ than the state‐centred focus of security policy during the Cold War period. Among the most enthusiastic proponents of the human security paradigm in t...
Philip D. Dunne, Helen G. Coleman, Peter Bankhead, Matthew Alderdice et al.
Purpose: BRAF mutation occurs in 8-15% of colon cancers (CC), and is associated with poor prognosis in metastatic disease. Compared to wild-type BRAF (BRAFWT) disease, stage II/III CC patients with BRAF mutant (BRAFMT) tumors have shorter overall survival after relapse; however, time-to-relapse is n...
Lydia A. Schoenpflug, Aikaterini Chatzipli, Korsuk Sirinukunwattana, Susan D. Richman et al.
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either through visual pathological review [conventional pathology (CP)] or the deconvolution of m...
Natalie C. Fisher, Sudhir B. Malla, Nigel B. Jamieson, Philip D. Dunne
Abstract In an era where transcriptomics-based subtyping, phenotyping and mechanistic understanding is increasingly being driven by state-of-the-art spatially resolved transcriptomic (ST) technologies, it is imperative that researchers, journals, and funders do all they can to ensure that as a commu...
Sarah Laing, Isabel Dye, R L Byrne, Eva Freckmann et al.
Although 30-40% of human Non-Small Cell lung cancers show low level amplification of c-MYC and genetic evidence supports c-Myc as a key downstream effector of KRas-driven tumourigenesis in mouse models, the functional contribution of MYC to human lung cancer remains unclear. We applied a phenotype-b...
Stephen T. McSorley, Tomoko Iwata, Aula Ammar, Sara SF Al-Badran et al.
Abstract Background Current British Society of Gastroenterology (BSG) guidelines misclassify metachronous lesion risk after polypectomy in approximately 40% of patients. Building on evidence that immune exclusion drives progression of adenomas to colorectal cancer, this study examined immune profile...
Zhichun Gao, Yuhan Gao, Louise Dutton, Grace Todd et al.
Abstract Gremlin1 is a member of a cysteine-knot containing family of secreted antagonists of bone morphogenetic protein signaling. GREM1 binding to BMP targets prevents their engagement with cognate BMP receptors, attenuating BMP-dependent gene expression. Some evidence suggests that GREM1 can dire...
Owen J. Sansom, Lucas Zeiger, Catriona A. Ford, Laura M. Millett et al.
Colorectal cancer (CRC) is a complex disease with key oncogenic pathways, including Wnt, MAPK, and PI3K, co-operating to drive tumour initiation and progression. Loss-of-function mutations in the Wnt-pathway inhibitor APC are the most prominent genetic alterations and are commonly seen as the tumour...
Shania M. Corry, Svetlana Sakhnevych, Noha Ehssan Mohamed, Sudhir B. Malla et al.
In colorectal cancer (CRC), tumours classified as consensus molecular subtype 4 (CMS4) have the worst prognosis and derive negligible benefit from chemotherapy. We previously described how repressed interferon-related signalling is associated with increased relapse in CMS4 tumours. Although the vira...
Darragh G. McArt, Philip D. Dunne, Elaine W. Kay, Anthony O’Grady et al.
3573 Background: Despite the use of 5-FU-based adjuvant therapies, a large proportion of stage III (locally advanced) colorectal cancer (CRC) patients will relapse and die of metastatic disease. Recent data from phase III trials using the anti-VEGF or the anti-EGFR mAbs have shown that, in contrast ...