Raju Dash, Rasel Das, Md. Junaid, Md. Forhad Chowdhury Akash et al.
Ebola virus (EBOV) is one of the lethal viruses, causing more than 24 epidemic outbreaks to date. Despite having available molecular knowledge of this virus, no definite vaccine or other remedial agents have been developed yet for the management and avoidance of EBOV infections in humans. Disclosing...
Raju Dash, Md. Chayan Ali, Nayan Dash, Md. Abul Kalam Azad et al.
Sulfotransferase 1A1 (SULT1A1) is responsible for catalyzing various types of endogenous and exogenous compounds. Accumulating data indicates that the polymorphism rs9282861 (R213H) is responsible for inefficient enzymatic activity and associated with cancer progression. To characterize the detailed...
Raju Dash, Md. Junaid, Sarmistha Mitra, Md. Arifuzzaman et al.
Vascular endothelial growth factor receptor-2 (VEGFR-2) is one of the regulatory elements of angiogenesis that is expressed highly in various diseases and is also essential for solid tumor growth. The present study was aimed at identifying potent inhibitors of VEGFR-2 by considering herbal secondary...
S. M. Zahid Hosen, Md. Nazim Uddin, Zhihong Xu, Benjamin J. Buckley et al.
Background Previous studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU ) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association of PLAU expression with factors that modulate P...
Tahmida Shamsuddin, Muhammad Shaiful Alam, Md. Junaid, Rasheda Akter et al.
BACKGROUND: Adhatoda vasica (Nees.) of the family Acanthaceae has been used in the Southeast tropical zone as it is efficacious against headache, colds, cough, whooping cough, fever, asthma, dyspnea, phthisis, jaundice, chronic bronchitis, and diarrhea. It exhibits commendable pharmacological activi...
Arafat Rahman Oany, Mamun Mia, Tahmina Pervin, Md. Junaid et al.
To date, the global COVID-19 pandemic has been associated with 11.8 million cases and over 545481 deaths. In this study, we have employed virtual screening approaches and selected 415 lead-like compounds from 103 million chemical substances, based on the existing drugs, from PubChem databases as pot...
Yeasmin Akter, Md. Junaid, Syeda Samira Afrose, Afsana Nahrin et al.
BACKGROUND: Linum usitatissimum or flax has been broadly utilized in numerous milieus worldwide as a primeval medicinal plant because of its health benefits in diverse types of diseases. OBJECTIVE: The objective of this review is to assemble the latest information on the botanical description, distr...
Raju Dash, Mir Muhammad Nasir Uddin, S. M. Zahid Hosen, Zahed Bin Rahim et al.
Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with tumor growth, infiltration, and metastasis in preclinical experiments. Known inhibitors against COX-2 exhibit toxicity. Therefore, it is of interest to screen natural compounds like flavanoids against COX-2. Mole...
Md. Muzahid Ahmed Ezaj, Md. Junaid, Yeasmin Akter, Afsana Nahrin et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the most cryptic pandemic outbreak of the 21st century, has gripped more than 1.8 million people to death and infected almost eighty six million. As it is a new variant of SARS, there is no approved drug or vaccine available against this ...
Raju Dash, Md. Arifuzzaman, Sarmistha Mitra, Md. Abdul Hannan et al.
BACKGROUND: Although protein kinase D1 (PKD1) has been proved to be an efficient target for anticancer drug development, lack of structural details and substrate binding mechanisms are the main obstacles for the development of selective inhibitors with therapeutic benefits. OBJECTIVE: The present st...
Raju Dash, S. M. Zahid Hosen, Md. Rezaul Karim, Mohammad Shah Hafez Kabir et al.
Epidermal Growth Factor Receptor (EGFR) is one of the four members of the Human Epidermal Receptor (HER) family, which is deregulated and over expressed in platinum resistant ovarian cancer. Thus, targeting EGFR receptor along with platinum drugs is one of the major strategies to increase the platin...
S. M. Zahid Hosen, Raju Dash, Mahmuda Khatun, Rasheda Akter et al.
Tyrosine kinases (KDR) have been considered as a potential targets for the design of new anticancer agents. Recently, a series of N-4-chlorophenylnaphthamides has been reported with KDR inhibitory activity. In order to demonstrate the pharmacokinetics and the relationship between the structures and ...
S. M. Zahid Hosen, Raju Dash, Md. Junaid, Sarmistha Mitra et al.
In SCF (Skp, Cullin, F-box) ubiquitin-protein ligase complexes, S-phase kinase 2 (SKP2) is one of the major players of F-box family, that is responsible for the degradation of several important cell regulators and tumor suppressor proteins. Despite of having significant evidence for the role of SKP2...
Lipi Rani Ray, Muhammad Shaiful Alam, Md. Junaid, Sakia Ferdousy et al.
BACKGROUND: Brassica oleracea var. capitata f. alba (white cabbage) is a cruciferous vegetable used as a vegetable and traditional medicine all over the world. Different preparation from several parts of the plant- roots, shoots, leaves, and the whole plant are used to treat a wide range of diseases...
Yeasmin Akter Munni, Md. Chayan Ali, Nusrat Jahan Selsi, Marium Sultana et al.
Traditional vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors can manage angiogenesis; however, severe toxicity and resistance limit their long-term applications in clinical therapy. Shikonin (SHK) and its derivatives could be promising to inhibit the VEGFR-2 mediated angiogenesis, ...