Nga Tran Vu Thieu, Tan Trinh Van, Anh Tran Tuan, Elizabeth J. Klemm et al.
OBJECTIVES: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of Bangladeshi febrile patients. METHODS: IgM against 12 purified antigens and t...
Kerstin Daniela Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra et al.
BACKGROUND: Improvements in the early diagnosis of dengue are urgently needed, especially in resource-limited settings where the distinction between dengue and other febrile illnesses is crucial for patient management. METHODS: In this prospective, observational study (IDAMS), we included patients a...
Zoe A. Dyson, Philip Ashton, Farhana Khanam, Angeziwa Chunga Chirambo et al.
BACKGROUND: Enteric fever is a serious public health concern. The causative agents, Salmonella enterica serovars Typhi and Paratyphi A, frequently have antimicrobial resistance (AMR), leading to limited treatment options and poorer clinical outcomes. We investigated the genomic epidemiology, resista...
Elin Näsström, Christopher M. Parry, Nga Tran Vu Thieu, Rapeephan R. Maude et al.
Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Näsström et al., 2014). Here, we performed ...
Muhamad Fachrul, Abhilasha Karkey, Mila Shakya, Louise M. Judd et al.
RNAseq data can be used to infer genetic variants, yet its use for estimating genetic population structure remains underexplored. Here, we construct a freely available computational tool (RGStraP) to estimate RNAseq-based genetic principal components (RG-PCs) and assess whether RG-PCs can be used to...
Sontosh K Deb, Divya Kalra, Jędrzej Kubica, Erik Stricker et al.
<ns3:p>Background The goal of the Fifth Annual Baylor College of Medicine & DNAnexus Structural Variation Hackathon was to push forward the research on structural variants (SVs) by rapidly developing and deploying open-source software. The event took place in-person and virtually in August 2023,...
Joseph W. Walker, Paula Russell, Leanne M. Kermack, Tan Trinh Van et al.
Serologic surveillance of at-risk populations can be used to directly estimate the incidence of typhoidal Salmonella infection across a variety of settings, including those without access to facility-based blood-culture surveillance. We collected paired blood samples approximately three months apart...
Lê Văn Cường, Long Lâm Nhật, Khương Hữu Thắng, Nguyễn Trọng Phú et al.
Trà hoa vàng bù gia mập (Camellia bugiamapensis Orel & Luu sp. Nov.) là loài cây đặc hữu, có giá trị cao về mặt y học và bảo tồn. Bài báo này được thực hiện nhằm cung cấp những thông tin chi tiết về đặc điểm sinh thái học của loài Trà hoa vàng bù gia mập, phân bố tự nhiên tại Vườn Quốc gia Bù Gi...
Russell J. Gray, Tan Van Nguyen, Long Nhat Cao, Mai Thi Trinh et al.
Abstract The U Minh wetlands of southern Vietnam in Ca Mau and Kieng Giang provinces are a degraded, peat-swamp wetland mosaic known to retain several globally threatened species. We deployed intensive, targeted camera-traps across U Minh Thuong National Park and U Minh Ha National Park from Decembe...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
<div> Serologic surveillance of at-risk populations can be used to directly estimate the incidence of typhoidal <i><i>Salmonella</i></i> infection across a variety of settings, including those without access to facility-based blood-culture surveillance. We collected paired blood samples approximatel...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
Each panel corresponds to the specific antigen target which was used to classify participants’ infection status when calculating seroincidence. Solid lines denote the median seroincidence (y-axis) in each age group (x-axis). Vertical lines represent the 95% credible intervals of the seroincidence es...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
Each panel corresponds to a specific antigen target against which IgG antibodies were measured. Solid lines denote the median of the log10-transformed fluorescence intensity (FI, a proxy for IgG concentration, y-axis) across participant’s baseline samples in each age group (x-axis). Vertical lines r...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
Each panel is a histogram of the posterior probability of infection (as indicated by a large rise in IgG) for participants who experienced an increase in IgG between the baseline and follow-up visits. Participants who experienced a decrease in IgG between visits were assumed to have not been infecte...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
Each panel corresponds to a different study site. Lines denote the estimated seroincidence (y-axis) in each age group (x-axis). Solid lines represent seroincidence estimates based on the serologic data generated in this study with a bead-based multiplex assay, while the dashed lines depict previousl...
Jo Walker (22404069), Paula Russell (11831692), Leanne Kermack (22404072), Tan Trinh Van (4261456) et al.
IgG measurements refer to standardized log-transformed fluorescence intensity (see methods). Panels in the top, middle, and bottom rows correspond to the Bangladesh, Malawi, and Nepal study sites, respectively. In each panel, each point represents the anti-HlyE IgG at baseline (x-axis) and the chang...