Aditya K. Gupta, Mesbah Talukder, Ted Rosén, Vincent Piguet
The current 2022 mpox (monkeypox) outbreak has been officially recognized as a public health emergency. The mpox clinical symptoms include high fever, fatigue, chills, headache, swollen lymph nodes, muscle aches, and a disseminated painful rash. However, recent cases of mpox have shown a shift in cl...
Aditya K. Gupta, Mesbah Talukder, Jessie Carviel, Elizabeth A. Cooper et al.
Antifungal resistance has become prevalent worldwide. Understanding the factors involved in spread of resistance allows the formulation of strategies to slow resistance development and likewise identify solutions for the treatment of highly recalcitrant fungal infections. To investigate the recent e...
Aditya K. Gupta, Tong Wang, Avantika Mann, Shruthi Polla Ravi et al.
INTRODUCTION: infections. This species is usually poorly responsive to terbinafine. AREAS COVERED: . Terbinafine has become less effective as a first-line agent attributed to mutations in the squalene epoxidase gene (Leu393Phe, Phe397Leu). Alternative therapies include itraconazole for a longer time...
Aditya K. Gupta, Susmita Susmita, Hien C. Nguyen, Amanda Liddy et al.
There has been a recent shift in the epidemiology of superficial fungal infections (tinea, dermatophytosis, dermatomycoses). Trichophyton indotineae is an emerging dermatophyte species of significant global concern for its contagious nature and antifungal drug resistance. This scoping review include...
Aditya K. Gupta, Mesbah Talukder, Tong Wang, Roxana Daneshjou et al.
Aditya K. Gupta, Mary A. Bamimore, Husam Abdel‐Qadir, Greg Williams et al.
BACKGROUND: Low-dose oral minoxidil (LDOM) is used to treat hair loss, but the literature on its safety profile is relatively sparse. AIMS: Using the FDA Adverse Event Reporting System (FAERS) database, we determined signals for adverse events (AEs) with LDOM use. METHODS: Four sets of case/noncase ...
Aditya K. Gupta, Mary A. Bamimore, Paradi Mirmirani, Vincent Piguet et al.
ABSTRACT Background Scant evidence exists for the relative efficacy of therapies for alopecia areata (AA)—including those approved by the Food and Drug Administration, namely, baricitinib, deuruxolitinib, and ritlecitinib. Aims We determined the relative efficacy and safety of monotherapy with janus...
Aditya K. Gupta, Mary A. Bamimore, Robert S. Haber, Greg Williams et al.
BACKGROUND: While oral minoxidil (OM) has been associated with pericardial effusion (PE), its etiology is presently inconclusive. AIMS: We characterized patient- and drug-related factors across reports from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) for PE ...
Aditya K. Gupta, Mary A. Bamimore, Vasiliki Economopoulos, Mesbah Talukder et al.
BACKGROUND: The number of monotherapies for hidradenitis suppurativa (HS) has expanded. However, the efficacy of active comparators has not been determined in head-to-head trials. AIMS: We conducted an NMA to determine the relative efficacy and safety of monotherapies for HS. METHODS: The literature...
Aditya K. Gupta, Mary A. Bamimore, Julien Sénéschal, Vincent Piguet et al.
BACKGROUND: Vitiligo, a stigmatizing condition characterized by patchy depigmented skin, has an estimated global prevalence of 0.36%. This condition is a risk factor for anxiety, depression, and even suicidal ideation. Hitherto, no network meta-analysis has investigated the relative effect of vitili...
Aditya K. Gupta, Mary A. Bamimore, Tong Wang, Shruthi Polla Ravi et al.
BACKGROUND: Care for actinic keratosis (AK) can be improved with more knowledge on the relative of effect of indicated therapies. OBJECTIVES: Using network meta-analyses, we quantitatively determined the comparative "short-term" effects of interventions in adults with facial and scalp AK. METHODS: O...
Aditya K. Gupta, Mary A. Bamimore, Tong Wang, Tina Bhutani et al.
Background and Objectives: Palmoplantar pustulosis (PPPust) and palmoplantar psoriasis (PPso) are distinct palm/sole dermatoses that have historically shared the abbreviation “PPP”. Though the two—since the advent of advanced biotechnology—are now deemed separate diagnoses, each still falls under th...
Aditya K. Gupta, Mary A. Bamimore, Tong Wang, Vincent Piguet et al.
BACKGROUND: Recently, the literature has expanded with peer-reviewed studies on immunomodulatory agents' efficacy on scalp psoriasis-which, in turn, widened knowledge gaps regarding these agents' relative effectiveness. We determined the relative efficacy of immunomodulatory monotherapies for scalp ...
Aditya K. Gupta, Mary A. Bamimore, Tong Wang, Mesbah Talukder et al.
Background—Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disorder—and evidence regarding relative impact of treatments thereof is currently scant. Objective—We aimed to systematically review and narratively synthesize comparative interventional therapies for GPP and sec...