Xiaoyang Zheng, Haven Baker, William S. Hancock, F Fawaz et al.
Fetal bovine serum (FBS) is the most widely used growth supplement for cell cultures, primarily because of its high levels of growth stimulatory factors and low levels of growth inhibitory factors. Maintaining successful and consistent cell fermentations can be difficult, as FBS is a complex natural...
Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Xiaoli Shi, Xinyi Wang, Wentao Yao, Dong-Min Shi et al.
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain of cancer biology have shed light on the molecular aspects ...
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Background: serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). Methods: This is a meta-analysis of global genotype and anti...
Farah Naz Qamar, Mohammad Tahir Yousafzai, Irum Fatima Dehraj, Sadia Shakoor et al.
BACKGROUND: Clinicians have limited therapeutic options for enteric as a result of increasing antimicrobial resistance, and therefore typhoid vaccination is recommended as a preventive measure. As a part of the Surveillance for Enteric Fever in Asia Project (SEAP), we investigated the extent measure...
Megan E. Carey, Ruby Jain, M. Yousuf, Mailis Maes et al.
BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) pose a major threat to the effective treatment and control of typhoid fever. The ongoing outbreak of extensively drug-resistant Salmonella Typhi (S. Typhi) in Pakistan has left azithromycin as the only remaining broadly efficacio...
Md. Shafiullah Parvej, K. H. M. Nazmul Hussain Nazir, M. Bahanur Rahman, Mueena Jahan et al.
AIM: Salmonella is an important zoonotic pathogen responsible for animal and human diseases. The aim of the present study was to determine the prevalence and stereotyping of Salmonella isolates isolated from apparently healthy poultry. Furthermore, the clonal relatedness among the isolated Salmonell...
Richelle C. Charles, Jason B. Harris, Michael R. Chase, Lauren M. Lebrun et al.
BACKGROUND: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic typhoidal illness in mice. The PhoP regulon is a well studied two component...
Xiangke Duan, Xue Huang, Xiaoyu Wang, Shuangquan Yan et al.
BACKGROUND: The increase in multiple antimicrobial-resistant bacteria seriously threatens global public health. Novel effective strategies are urgently needed. l-Serine was reported as the most effective amino acid inhibitor against bacterial growth and can sensitize Escherichia coli cells to gentam...
Rizwana Afroz, E. M. Tanvir, Mousumi Tania, Junjiang Fu et al.
BACKGROUND: Cancer cells are usually recognized as foreign particles by the immune cells. Mounting evidence suggest an important link between toll-like receptors (TLRs) and carcinogenesis. This review article focused on the role of TLRs, especially TLR4, in breast cancer. METHODS: Research data on T...
Md Salman Shakil, Md. Ashraful Hasan, Satya Ranjan Sarker
BACKGROUND: Breast cancer is the second leading cause of death in women worldwide. The extremely fast rate of metastasis and ability to develop resistance mechanism to all the conventional drugs make them very difficult to treat which are the causes of high morbidity and mortality of breast cancer p...
Robert Villafañe, Milka Zayas, Eddie B. Gilcrease, Andrew M. Kropinski et al.
BACKGROUND: The presence of prophages has been an important variable in genetic exchange and divergence in most bacteria. This study reports the determination of the genomic sequence of Salmonella phage epsilon 34, a temperate bacteriophage that was important in the early study of prophages that mod...
Nga Tran Vu Thieu, Tan Trinh Van, Anh Tran Tuan, Elizabeth J. Klemm et al.
OBJECTIVES: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of Bangladeshi febrile patients. METHODS: IgM against 12 purified antigens and t...
Sunjukta Ahsan, Sahida Rahman
OBJECTIVE: Salmonella enterica serovars Typhi and Paratyphi, the causative agents of typhoid and paratyphoid, are major threats in developing countries. The present study aimed to investigate the resistance pattern of 40 clinically isolated Salmonella enterica serovars Typhi (n = 33) and Paratyphi (...
S. Aravinth Vijay Jesuraj, Md. Moklesur Rahman Sarker, Long Chiau Ming, S. Marylin Jeya Praya et al.
Microbial anti-cancer enzymes have been proven to be effective and economical agents for cancer treatment. Aeromonas veronii has been identified as a microorganism with the potential to produce L-glutaminase, an anticancer agent effective against acute lymphocytic leukaemia. In this study, a selecti...