Lei Qiao, Jing Ma, Zihao Zhang, Wenhai Sui et al.
Rationale: The NLRP3 (NLR [NOD-like receptor] family, pyrin domain containing 3) inflammasome is an important driver of atherosclerosis. Our previous study shows that chaperone-mediated autophagy (CMA), one of the main lysosomal degradative process, has a regulatory role in lipid metabolism of macro...
Jing Zhou, Xiaohua Wang, Yixin Zhao, Cheng Chen et al.
Background: Cancer-associated fibroblasts (CAFs) have been shown to be among the most prominent cells in tumor microenvironment and play a significant role in accelerating tumor metastasis by interacting with other type of cells. Tumor-associated macrophages (TAMs), the predominant tumor-infiltratin...
Yang Yang, Qiaoyun Lai, Sakil Mahmud, Jiangyan Lu et al.
Eirini Karamariti, Chungang Zhai, Baoqi Yu, Lei Qiao et al.
Objective— DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in vascular disease. This study aims to assess the effec...
Lei Qiao, Hefeng Wang, Lei Xiang, Jing Ma et al.
Chaperone-mediated autophagy (CMA) serves as a critical upstream regulator of lipophagy and lipid metabolism in hepatocyte. However, the role of CMA in lipid metabolism of macrophage, the typical component of atherosclerotic plaque, remains unclear. In our study, LAMP-2A (L2A, a CMA marker) was redu...
Yuan Liang, Rui Zhang, Siddhartha Biswas, Qingfa Bu et al.
Abstract Non‐alcoholic fatty liver disease (NAFLD) has emerged as the primary risk factor for hepatocellular carcinoma (HCC), owing to improved vaccination rates of Hepatitis B and the increasing prevalence of metabolic syndrome related to obesity. Although the importance of innate and adaptive immu...
Jing Ma, Xiaoling Liu, Lei Qiao, Linlin Meng et al.
BACKGROUND: Progression of nontarget lesions (NTLs) after percutaneous coronary intervention (PCI) has been reported. However, it remains unknown whether progression of NTLs was causally related to stenting. This study was undertaken to test the hypothesis that stent implantation triggers acute phas...
Zunzhe Wang, Huating Wang, Chenghu Guo, Fangpu Yu et al.
The pathological proliferation of cells in vascular smooth muscle underlies neointimal hyperplasia (NIH) development during atherosclerosis. Circular RNAs (circRNAs), which represent novel functional biomarkers and RNA-binding proteins, contribute to multiple cardiovascular diseases; however, their ...
Qiao Liu, Yanli Luo, Zerui Li, Chen Chen et al.
EGFR inhibitors represent a significant milestone for treatment of non-small cell lung cancer, however, they suffer from the acquired drug resistance. Utilizing osimertinib as the lead compound, this work has explored the structural modifications on the indole and pyrimidine rings of osimertinib to ...
Yufeng Liu, Shengdian Jiang, Yingxin Li, Sujun Zhao et al.
We conducted a large-scale whole-brain morphometry study by analyzing 3.7 peta-voxels of mouse brain images at the single-cell resolution, producing one of the largest multi-morphometry databases of mammalian brains to date. We registered 204 mouse brains of three major imaging modalities to the All...
Jie Xiong, Xinran Cao, Shiyuan Qiao, Shiran Yu et al.
BACKGROUND: (Pro)renin receptor (PRR), a novel member of the renin-angiotensin system, participates in various cardiovascular diseases. However, the role of PRR in alcoholic cardiomyopathy (ACM), which is caused by alcohol intake and manifests as myocardial damage and cardiac dysfunction, remains un...
Guangqiong Xu, Qiao Weng, Lei Zhang, Yaye Song et al.
Abstract Aurora kinase B (AURKB) is an attractive and potential molecular target for cervical cancer therapy. To date, a variety of AURKB inhibitors are developed to suppress cervical tumors. Nevertheless, direct use of these small molecule inhibitors may cause severe side effects to patients, limit...
Leilei Xu, Feng Zhu, Zezhang Zhu, Zhen Liu et al.
STUDY DESIGN: A prospective, randomized, and controlled clinical trial. OBJECTIVE: To compare surgical zipper with subcuticular Monocryl sutures in terms of incision closure time, cosmetic results, and the complication rate in patients with adolescent idiopathic scoliosis (AIS) undergoing posterior ...
Jiaming Li, Mengmeng Jiang, Qiaoran Wang, Zikai Zheng et al.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluatio...
Qiao Xiao-ying, Wenke Wang, Lei Duan, Yanlin Wang et al.