Ying‐Ying Zheng, Yi‐Tong Ma, Jinying Zhang, Xiang Xie
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be g...
Huaipin Zhang, Dong Yue, Chunxia Dou, Wei Zhao et al.
This paper is concerned with data-driven distributed optimal consensus control for unknown multiagent systems (MASs) with input delays. The input-delayed MAS model is first converted into a delay-free form using a model reduction method. By establishing an equivalent relationship on the predesigned ...
Yimin Wang, Qi Li, Lijuan Liu, Zhi Zhou et al.
Neuron morphology is recognized as a key determinant of cell type, yet the quantitative profiling of a mammalian neuron's complete three-dimensional (3-D) morphology remains arduous when the neuron has complex arborization and long projection. Whole-brain reconstruction of neuron morphology is even ...
Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao et al.
BACKGROUND: DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a DNMT3A promoter genetic variant on its transcriptional activity and to evaluate...
Abualgasim Elgaili Abdalla, Nzungize Lambert, Xiangke Duan, Jianping Xie
The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress...
Ruipeng Chen, Xin Du, Yujun Cui, Xieyuan Zhang et al.
Abstract There is a great demand for the development of detection assays for inflammation infection diagnosis with high throughput and ultrasensitivity. Herein, a vertical flow assay system with functionalized nanoporous anodic aluminum oxide (AAO) as sensing membrane, and encoded core–shell surface...
Xiangke Duan, Xue Huang, Xiaoyu Wang, Shuangquan Yan et al.
BACKGROUND: The increase in multiple antimicrobial-resistant bacteria seriously threatens global public health. Novel effective strategies are urgently needed. l-Serine was reported as the most effective amino acid inhibitor against bacterial growth and can sensitize Escherichia coli cells to gentam...
Qun Liang, Han Liu, Li-xiang Xie, Xue Li et al.
Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in the world.
Hafiz Ishfaq Ahmad, Muhammad Jamil Ahmad, Akhtar Rasool Asif, Muhammad Adnan et al.
Precise nucleic acid editing technologies have facilitated the research of cellular function and the development of novel therapeutics, especially the current programmable nucleases-based editing tools, such as the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-associ...
Xiangke Duan, Yunsong Li, Qinglin Du, Qinqin Huang et al.
Bacterial persisters, usually slow-growing, non-replicating cells highly tolerant to antibiotics, play a crucial role contributing to the recalcitrance of chronic infections and treatment failure. Understanding the molecular mechanism of persister cells formation and maintenance would obviously insp...
Mengmeng Ji, Lingbin Du, Zhimin Ma, Junxing Xie et al.
Abstract Chronic inflammation has been associated with the development of lung cancer. In this study, we examined the association between C‐reactive protein (CRP) and lung cancer in a prospective cohort study and used Mendelian randomization (MR) to clarify the causality. We included 420 977 partici...
Ying‐Ying Zheng, Yi‐Tong Ma, Jinying Zhang, Xiang Xie
tive Correspondence (Interaction between RAAS inhibitors and ACE2 in the context of COVID-19. Nat. Rev. Cardiol. https://doi.org/ 10.1038/s41569-020-0368-x (2020))1 on our Comment article (COVID-19 and the cardiovascular system. Nat. Rev. Cardiol. https://doi. org/10.1038/s41569-020-0360-5 (2020))2....
Xiangyu Fan, Longxiang Xie, Wu Li, Jianping Xie
BACKGROUND: Prophages, integral components of many bacterial genomes, play significant roles in cognate host bacteria, such as virulence, toxin biosynthesis and secretion, fitness cost, genomic variations, and evolution. Many prophages and prophage-like elements present in sequenced bacterial genome...
Xiaohong Xiang, Wanyan Deng, Minqiang Liu, Jianping Xie
Many bacteria can develop biofilm (BF), a multicellular structure largely combining bacteria and their extracellular polymeric substances (EPS). The formation of biofilm results in an alternative existence in which microbes ensure their survival in adverse environments. Biofilm-relevant infections a...
Quanxin Long, Xiaohong Xiang, Qing-qin Yin, Shuangjiang Li et al.
Mycobacterium tuberculosis, the leading causative agent of tuberculosis, remains one of the most deadly infectious pathogens. PE_PGRS proteins become a new focus as their species specificity in mycobacteria, especially in pathogenic mycobacteria. Despite intensive research, PE_PGRS proteins are stil...